Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5900.067 | 0.0388 | -0.4743 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5900.067 | 0.0423 | -0.4551 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5900.067 | 0.0574 | -0.3825 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5900.067 | 0.0035 | -0.8045 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5901.067 | 1.0107 | 1.0114 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5901.067 | 1.0038 | 1.0041 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5901.067 | 1.0110 | 1.0117 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5901.067 | 0.9343 | 0.9288 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5901.067 | 0.0310 | -0.6860 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5901.067 | 0.0318 | -0.6819 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5901.067 | 0.0356 | -0.6620 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5901.067 | 0.0380 | -0.6501 | 1.8762 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5901.067 | 0.0035 | -0.9025 | 1.8762 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5902.067 | 1.0253 | 1.0430 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5902.067 | 0.9852 | 0.9747 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5902.067 | 0.9772 | 0.9611 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5902.067 | 0.9043 | 0.8359 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5902.067 | 0.4201 | -0.0440 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 5902.067 | 0.4086 | -0.0663 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 5902.067 | 0.4329 | -0.0193 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 5902.067 | 0.4011 | -0.0809 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 5902.067 | 0.0048 | -0.9786 | 1.1750 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5903.067 | 0.9658 | 0.9454 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5903.067 | 0.9718 | 0.9550 | 1.2584 | |
| BT-20 | TNBC | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5903.067 | 0.9596 | 0.9355 | 1.2584 |