Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 184B5 | NM | Basal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5897.067 | 0.0491 | -0.8408 | 1.1908 | |
| 184B5 | NM | Basal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5897.067 | 0.0086 | -0.9633 | 1.1908 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5898.067 | 0.9761 | 0.9273 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5898.067 | 0.9830 | 0.9483 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5898.067 | 1.0025 | 1.0078 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5898.067 | 0.7268 | 0.2269 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5898.067 | 0.6351 | -0.0020 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5898.067 | 0.6029 | -0.0783 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5898.067 | 0.6289 | -0.0168 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5898.067 | 0.3979 | -0.5123 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5898.067 | 0.0087 | -0.9986 | 0.6532 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5899.067 | 0.9705 | 0.9405 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5899.067 | 0.9502 | 0.8994 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5899.067 | 0.9806 | 0.9609 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5899.067 | 0.9336 | 0.8658 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5899.067 | 0.3517 | -0.3041 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 5899.067 | 0.3080 | -0.3915 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 5899.067 | 0.3411 | -0.3253 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 5899.067 | 0.2750 | -0.4573 | 0.9897 | |
| 600MPE | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 5899.067 | 0.0015 | -0.9973 | 0.9897 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 5900.067 | 1.0539 | 1.0437 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 5900.067 | 1.0585 | 1.0473 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 5900.067 | 1.0377 | 1.0307 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 5900.067 | 0.9630 | 0.9692 | 2.4324 | |
| AU565 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 5900.067 | 0.0449 | -0.4414 | 2.4324 |