Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10581.137 | 0.9593 | 0.9318 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10581.137 | 1.0378 | 1.0629 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10581.137 | 0.9630 | 0.9380 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10581.137 | 0.7138 | 0.5092 | 1.1975 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000128 | uM | 11854.161 | 1.0284 | 1.0469 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00064 | uM | 11854.161 | 0.9525 | 0.9210 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0032 | uM | 11854.161 | 0.9934 | 0.9890 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.016 | uM | 11854.161 | 1.0378 | 1.0624 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.08 | uM | 11854.161 | 1.0122 | 1.0202 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.4 | uM | 11854.161 | 1.0465 | 1.0767 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 2 | uM | 11854.161 | 1.0214 | 1.0353 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 10 | uM | 11854.161 | 1.0940 | 1.1544 | 1.2085 | |
| BT-20 | TNBC | Basal A | L-779450 | BRAF | MAPK | 50 | uM | 11854.161 | 0.2522 | -0.3604 | 1.2085 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12056.161 | 1.0242 | 1.0520 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12056.161 | 0.9191 | 0.8269 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12056.161 | 1.0251 | 1.0539 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.016 | uM | 12056.161 | 1.0718 | 1.1545 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.08 | uM | 12056.161 | 1.0058 | 1.0124 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12056.161 | 1.0289 | 1.0622 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12056.161 | 0.9095 | 0.8065 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12056.161 | 0.9477 | 0.8880 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12056.161 | 0.0401 | -0.9365 | 0.9322 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.000128 | uM | 12178.161 | 1.0204 | 1.0717 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.00064 | uM | 12178.161 | 1.0033 | 1.0114 | 0.5721 | |
| BT-474 | HER2amp | Luminal | L-779450 | BRAF | MAPK | 0.0032 | uM | 12178.161 | 1.0439 | 1.1560 | 0.5721 |