Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | ICRF-193 | TOP2 | TOP | 50 | uM | 12254.157 | 0.8727 | 0.8457 | 1.6969 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10817.151 | 0.9831 | 0.9772 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10817.151 | 0.9664 | 0.9545 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10817.151 | 0.9907 | 0.9874 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10817.151 | 0.9801 | 0.9731 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10817.151 | 0.9177 | 0.8876 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10817.151 | 0.6916 | 0.5601 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10817.151 | 0.5792 | 0.3846 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10817.151 | 0.5857 | 0.3950 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10817.151 | 0.5620 | 0.3567 | 1.4848 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12365.157 | 0.9562 | 0.9605 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12365.157 | 0.9926 | 0.9934 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12365.157 | 0.9991 | 0.9992 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12365.157 | 0.9692 | 0.9724 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12365.157 | 0.7411 | 0.7503 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12365.157 | 0.5473 | 0.5294 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 2 | uM | 12365.157 | 0.5773 | 0.5662 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 10 | uM | 12365.157 | 0.5522 | 0.5354 | 2.2468 | |
| MCF12A | NM | Basal B | ICRF-193 | TOP2 | TOP | 50 | uM | 12365.157 | 0.5471 | 0.5291 | 2.2468 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10997.151 | 0.9254 | 0.8861 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10997.151 | 0.9233 | 0.8830 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10997.151 | 0.9483 | 0.9213 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10997.151 | 0.9654 | 0.9474 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10997.151 | 0.9649 | 0.9467 | 1.3229 | |
| MCF7 | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10997.151 | 0.9505 | 0.9246 | 1.3229 |