Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 1.33 | uM | 7504.067 | 0.3239 | 0.1234 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 6.67 | uM | 7504.067 | 0.1810 | -0.1659 | 1.9544 | |
| MDA-MB-231 | TNBC | Basal B | Ispinesib | KSP | Kinesin | 33.3 | uM | 7504.067 | 0.0003 | -0.9685 | 1.9544 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7506.067 | 1.0941 | 1.1809 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7506.067 | 1.0432 | 1.0830 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7506.067 | 1.0188 | 1.0361 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7506.067 | 1.0648 | 1.1247 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7506.067 | 0.4372 | -0.0985 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7506.067 | 0.4070 | -0.1584 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7506.067 | 0.4387 | -0.0956 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7506.067 | 0.4580 | -0.0572 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7506.067 | 0.0107 | -0.9746 | 1.0384 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7507.067 | 1.0068 | 1.0138 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7507.067 | 0.9971 | 0.9940 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7507.067 | 0.9920 | 0.9839 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7507.067 | 0.9700 | 0.9392 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7507.067 | 0.6610 | 0.3154 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7507.067 | 0.3390 | -0.3308 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7507.067 | 0.3884 | -0.2320 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7507.067 | 0.3819 | -0.2452 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7507.067 | 0.0070 | -0.9869 | 0.9880 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7508.067 | 0.9542 | 0.8797 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7508.067 | 0.9971 | 0.9923 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7508.067 | 0.9716 | 0.9251 | 0.7560 | |
| MDA-MB-361 | HER2amp | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7508.067 | 1.0107 | 1.0283 | 0.7560 |