Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset - HMS LINCS Database

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)

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Small molecules	Cells	Antibodies

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Cell	Clinical Subtype	Transcriptional Subtype	Small Molecule	Perturbagen Target	Perturbagen Class	Perturbagen Concentration	Perturbagen Conc Unit	Biological Replicate ID	Relative Cell Count	Normalized Growth Rate Inhibition Value	Nominal Division Rate
MDA-MB-157	TNBC	Basal B	Ispinesib	KSP	Kinesin	33.3	uM	7498.067	0.0131	-0.9562	1.1346
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0000853	uM	7499.067	0.9827	0.9556	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.000427	uM	7499.067	0.9381	0.8418	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.00213	uM	7499.067	1.0061	1.0158	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0107	uM	7499.067	1.0094	1.0243	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0533	uM	7499.067	0.7615	0.4077	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.267	uM	7499.067	0.7819	0.4566	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	1.33	uM	7499.067	0.7683	0.4239	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	6.67	uM	7499.067	0.6504	0.1489	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	33.3	uM	7499.067	0.0006	-0.9999	0.7759
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0000853	uM	7500.067	0.9444	0.8460	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.000427	uM	7500.067	0.9592	0.8866	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.00213	uM	7500.067	0.9559	0.8775	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0107	uM	7500.067	1.0399	1.1125	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.0533	uM	7500.067	0.7892	0.4359	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	0.267	uM	7500.067	0.5825	-0.0614	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	1.33	uM	7500.067	0.8132	0.4973	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	6.67	uM	7500.067	0.5811	-0.0645	0.7143
MDA-MB-175-VII	HR+	Luminal	Ispinesib	KSP	Kinesin	33.3	uM	7500.067	0.0034	-0.9993	0.7143
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.0000853	uM	7504.067	1.0682	1.0687	1.9544
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.000427	uM	7504.067	1.1935	1.1894	1.9544
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.00213	uM	7504.067	1.0764	1.0768	1.9544
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.0107	uM	7504.067	0.9540	0.9524	1.9544
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.0533	uM	7504.067	0.3725	0.2066	1.9544
MDA-MB-231	TNBC	Basal B	Ispinesib	KSP	Kinesin	0.267	uM	7504.067	0.3765	0.2132	1.9544

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HMS LINCS Project

Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)