Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7837.001 | 0.1105 | -0.5234 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7837.001 | 0.1177 | -0.5035 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7837.001 | 0.0568 | -0.6911 | 1.5358 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7839.001 | 1.0491 | 1.0513 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7839.001 | 0.8300 | 0.8124 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7839.001 | 1.0741 | 1.0770 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7839.001 | 0.8793 | 0.8685 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7839.001 | 0.2277 | -0.0852 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7839.001 | 0.1671 | -0.2232 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7839.001 | 0.1671 | -0.2232 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7839.001 | 0.1591 | -0.2431 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7839.001 | 0.0536 | -0.5742 | 1.8919 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9386.001 | 1.0482 | 1.0724 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9386.001 | 0.9347 | 0.9006 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9386.001 | 1.0577 | 1.0865 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9386.001 | 0.9490 | 0.9225 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9386.001 | 0.2333 | -0.3337 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9386.001 | 0.1408 | -0.5450 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9386.001 | 0.1540 | -0.5130 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9386.001 | 0.1406 | -0.5455 | 1.3243 | |
| HCC1954 | HER2amp | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9386.001 | 0.0810 | -0.7003 | 1.3243 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7841.001 | 0.8906 | 0.6152 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7841.001 | 1.0383 | 1.1434 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7841.001 | 0.9530 | 0.8301 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7841.001 | 0.9003 | 0.6478 | 0.5424 |