Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7841.001 | 0.5933 | -0.2361 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7841.001 | 0.5208 | -0.3994 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7841.001 | 0.5275 | -0.3851 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7841.001 | 0.5002 | -0.4424 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7841.001 | 0.2678 | -0.8239 | 0.5424 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7844.001 | 0.9378 | 0.6214 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7844.001 | 0.9572 | 0.7333 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7844.001 | 0.9198 | 0.5216 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7844.001 | 1.0024 | 1.0160 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7844.001 | 0.7758 | -0.1275 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7844.001 | 0.6986 | -0.3807 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7844.001 | 0.6851 | -0.4190 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7844.001 | 0.6355 | -0.5456 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7844.001 | 0.4119 | -0.8899 | 0.3060 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9402.001 | 0.7482 | 0.2857 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9402.001 | 0.7567 | 0.3081 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9402.001 | 0.7452 | 0.2779 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9402.001 | 1.0487 | 1.1501 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9402.001 | 0.6371 | 0.0067 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9402.001 | 0.5572 | -0.1792 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9402.001 | 0.5023 | -0.2991 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9402.001 | 0.5331 | -0.2326 | 0.6567 | |
| HCC202 | HER2amp | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9402.001 | 0.4859 | -0.3335 | 0.6567 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7848.001 | 1.0686 | 1.3139 | 0.4548 | |
| HCC2185 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7848.001 | 0.9883 | 0.9489 | 0.4548 |