Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10695.151 | 1.0050 | 1.0067 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10695.151 | 0.9684 | 0.9570 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10695.151 | 0.6846 | 0.5475 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10695.151 | 0.5059 | 0.2610 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10695.151 | 0.7243 | 0.6077 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 11852.157 | 1.0241 | 1.0339 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 11852.157 | 0.9775 | 0.9681 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 11852.157 | 1.0233 | 1.0328 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.016 | uM | 11852.157 | 0.9894 | 0.9850 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.08 | uM | 11852.157 | 1.0441 | 1.0618 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.4 | uM | 11852.157 | 0.8354 | 0.7616 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 2 | uM | 11852.157 | 0.6571 | 0.4872 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 10 | uM | 11852.157 | 0.7014 | 0.5573 | 1.4174 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 50 | uM | 11852.157 | 0.4450 | 0.1296 | 1.4174 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10939.151 | 0.9316 | 0.9202 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10939.151 | 0.9871 | 0.9851 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10939.151 | 0.9888 | 0.9871 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10939.151 | 0.9607 | 0.9544 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 10939.151 | 0.9748 | 0.9709 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.267 | uM | 10939.151 | 0.8795 | 0.8576 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10939.151 | 0.8663 | 0.8415 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10939.151 | 0.7753 | 0.7276 | 1.7384 | |
| T47D | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10939.151 | 0.8737 | 0.8505 | 1.7384 | |
| T47DKBLUC | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 12608.171 | 0.9519 | 0.9095 | 1.0643 | |
| T47DKBLUC | Unknown | Unknown | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 12608.171 | 0.9496 | 0.9051 | 1.0643 |