Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7801.001 | 0.5426 | -0.3553 | 0.5402 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9186.001 | 1.0146 | 1.0571 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9186.001 | 0.9773 | 0.9131 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9186.001 | 1.0191 | 1.0745 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9186.001 | 0.9935 | 0.9749 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9186.001 | 0.8226 | 0.3703 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9186.001 | 0.8229 | 0.3712 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9186.001 | 0.8007 | 0.3006 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9186.001 | 0.7892 | 0.2645 | 0.5165 | |
| BT-483 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9186.001 | 0.6864 | -0.0348 | 0.5165 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 10261.001 | 1.1200 | 1.0989 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 10261.001 | 0.9933 | 0.9943 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 10261.001 | 1.0994 | 1.0824 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 10261.001 | 1.0375 | 1.0316 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 10261.001 | 0.5620 | 0.5646 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 0.267 | uM | 10261.001 | 0.2995 | 0.1966 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 1.33 | uM | 10261.001 | 0.3335 | 0.2527 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 6.67 | uM | 10261.001 | 0.3212 | 0.2327 | 2.3472 | |
| BT-549 | TNBC | Basal B | GSK923295 | CENPE | Kinesin | 33.3 | uM | 10261.001 | 0.3061 | 0.2077 | 2.3472 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 9210.001 | 0.9928 | 0.9836 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 9210.001 | 1.0344 | 1.0788 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9210.001 | 0.9371 | 0.8571 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9210.001 | 1.0114 | 1.0259 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9210.001 | 0.6437 | 0.2096 | 0.8761 | |
| CAMA-1 | HR+ | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9210.001 | 0.4401 | -0.2163 | 0.8761 |