Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9889.001 | 0.9853 | 0.9799 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9889.001 | 0.9835 | 0.9774 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9889.001 | 0.3555 | -0.0134 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9889.001 | 0.2460 | -0.2327 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9889.001 | 0.2925 | -0.1364 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9889.001 | 0.3707 | 0.0154 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9889.001 | 0.3814 | 0.0353 | 1.4638 | |
| SUM52PE | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9889.001 | 0.0948 | -0.6000 | 1.4638 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9897.001 | 0.9980 | 0.9925 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9897.001 | 1.0161 | 1.0620 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9897.001 | 1.0683 | 1.2698 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9897.001 | 0.9669 | 0.8750 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9897.001 | 0.8253 | 0.3847 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9897.001 | 0.7470 | 0.1442 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9897.001 | 0.7987 | 0.3004 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9897.001 | 0.7361 | 0.1123 | 0.5223 | |
| T47D | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9897.001 | 0.0544 | -0.9924 | 0.5223 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7926.001 | 1.0949 | 1.2449 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7926.001 | 1.1959 | 1.5117 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7926.001 | 1.0617 | 1.1584 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7926.001 | 0.8478 | 0.6206 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7926.001 | 0.8431 | 0.6092 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7926.001 | 1.1253 | 1.3246 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7926.001 | 1.0238 | 1.0607 | 0.7852 | |
| UACC-812 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7926.001 | 1.0543 | 1.1393 | 0.7852 |