Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 1.33 | uM | 10579.139 | 0.8907 | 0.8047 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 6.67 | uM | 10579.139 | 0.8312 | 0.6972 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 33.3 | uM | 10579.139 | 1.0133 | 1.0236 | 1.1260 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.000128 | uM | 12098.157 | 1.0370 | 1.0564 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.00064 | uM | 12098.157 | 0.9906 | 0.9856 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.0032 | uM | 12098.157 | 0.9543 | 0.9297 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.016 | uM | 12098.157 | 1.0225 | 1.0344 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.08 | uM | 12098.157 | 1.1002 | 1.1517 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 0.4 | uM | 12098.157 | 0.8670 | 0.7931 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 2 | uM | 12098.157 | 1.0688 | 1.1045 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 10 | uM | 12098.157 | 0.8622 | 0.7855 | 1.3067 | |
| SUM225CWN | HER2amp | Basal A | ICRF-193 | TOP2 | TOP | 50 | uM | 12098.157 | 0.9724 | 0.9576 | 1.3067 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 11058.151 | 0.8987 | 0.9077 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 11058.151 | 0.9073 | 0.9158 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 11058.151 | 0.9166 | 0.9244 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 11058.151 | 0.9069 | 0.9154 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.0533 | uM | 11058.151 | 0.8814 | 0.8914 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 0.267 | uM | 11058.151 | 0.7520 | 0.7632 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 1.33 | uM | 11058.151 | 0.5033 | 0.4764 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 6.67 | uM | 11058.151 | 0.4072 | 0.3443 | 2.2617 | |
| SUM229PE | TNBC | - | ICRF-193 | TOP2 | TOP | 33.3 | uM | 11058.151 | 0.3790 | 0.3024 | 2.2617 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0000853 | uM | 10695.151 | 1.0138 | 1.0186 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.000427 | uM | 10695.151 | 0.9831 | 0.9771 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.00213 | uM | 10695.151 | 0.9828 | 0.9766 | 1.4773 | |
| SUM52PE | HR+ | Luminal | ICRF-193 | TOP2 | TOP | 0.0107 | uM | 10695.151 | 1.0823 | 1.1100 | 1.4773 |