Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 0.00427 | uM | 7517.093 | 1.0586 | 1.0780 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 0.0213 | uM | 7517.093 | 1.0305 | 1.0408 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 0.107 | uM | 7517.093 | 1.0036 | 1.0049 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 0.533 | uM | 7517.093 | 0.9218 | 0.8934 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 2.67 | uM | 7517.093 | 0.6764 | 0.5375 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 13.3 | uM | 7517.093 | 0.0081 | -0.9214 | 1.4869 | |
| MDA-MB-453 | TNBC | Luminal | IKK16 | IKK | NFKB | 66.7 | uM | 7517.093 | 0.0082 | -0.9207 | 1.4869 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.000171 | uM | 7527.093 | 1.0261 | 1.0287 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.000853 | uM | 7527.093 | 0.9590 | 0.9542 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.00427 | uM | 7527.093 | 0.9666 | 0.9627 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.0213 | uM | 7527.093 | 0.9616 | 0.9572 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.107 | uM | 7527.093 | 0.9726 | 0.9695 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 0.533 | uM | 7527.093 | 0.9324 | 0.9240 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 2.67 | uM | 7527.093 | 0.6858 | 0.6232 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 13.3 | uM | 7527.093 | 0.0378 | -0.6734 | 1.8070 | |
| SK-BR-3 | HER2amp | Luminal | IKK16 | IKK | NFKB | 66.7 | uM | 7527.093 | 0.0107 | -0.8372 | 1.8070 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.000171 | uM | 10381.093 | 1.0373 | 1.0762 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.000853 | uM | 10381.093 | 1.0586 | 1.1196 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.00427 | uM | 10381.093 | 0.9932 | 0.9862 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.0213 | uM | 10381.093 | 1.0421 | 1.0859 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.107 | uM | 10381.093 | 1.0232 | 1.0475 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 0.533 | uM | 10381.093 | 0.9064 | 0.8091 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 2.67 | uM | 10381.093 | 0.5892 | 0.1658 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 13.3 | uM | 10381.093 | 0.0060 | -0.9893 | 0.9799 | |
| SUM1315MO2 | TNBC | Basal B | IKK16 | IKK | NFKB | 66.7 | uM | 10381.093 | 0.0066 | -0.9882 | 0.9799 |