Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 9723.001 | 1.0737 | 1.1572 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 9723.001 | 0.9694 | 0.9349 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 9723.001 | 1.0465 | 1.0991 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 0.267 | uM | 9723.001 | 0.3965 | -0.2526 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 1.33 | uM | 9723.001 | 0.5336 | 0.0253 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 6.67 | uM | 9723.001 | 0.6767 | 0.3201 | 0.9400 | |
| MDA-MB-453 | TNBC | Luminal | GSK923295 | CENPE | Kinesin | 33.3 | uM | 9723.001 | 0.5841 | 0.1288 | 0.9400 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7904.001 | 1.0712 | 1.1014 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7904.001 | 0.8643 | 0.8011 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7904.001 | 1.0651 | 1.0927 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7904.001 | 0.7405 | 0.6117 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7904.001 | 0.2916 | -0.1751 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7904.001 | 0.1167 | -0.5729 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7904.001 | 0.1843 | -0.4068 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7904.001 | 0.2013 | -0.3680 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7904.001 | 0.1396 | -0.5140 | 1.3917 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0000853 | uM | 7905.001 | 1.0691 | 1.1882 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.000427 | uM | 7905.001 | 0.7887 | 0.4532 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.00213 | uM | 7905.001 | 1.1230 | 1.3378 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0107 | uM | 7905.001 | 0.8675 | 0.6519 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.0533 | uM | 7905.001 | 0.1187 | -0.8863 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 0.267 | uM | 7905.001 | 0.0733 | -0.9406 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 1.33 | uM | 7905.001 | 0.0996 | -0.9102 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 6.67 | uM | 7905.001 | 0.1343 | -0.8657 | 0.7433 | |
| MDA-MB-468 | TNBC | Basal A | GSK923295 | CENPE | Kinesin | 33.3 | uM | 7905.001 | 0.1151 | -0.8909 | 0.7433 |