Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7897.001 | 0.7387 | 0.3330 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7897.001 | 0.5954 | -0.0013 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7897.001 | 0.6807 | 0.1947 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7897.001 | 0.7773 | 0.4273 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7897.001 | 0.5585 | -0.0833 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7897.001 | 0.0106 | -0.9955 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9664.001 | 1.0144 | 1.0361 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9664.001 | 1.0057 | 1.0142 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9664.001 | 1.0261 | 1.0656 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9664.001 | 0.6833 | 0.2421 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9664.001 | 0.5117 | -0.1349 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9664.001 | 0.6568 | 0.1820 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9664.001 | 0.7925 | 0.4953 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9664.001 | 0.5688 | -0.0125 | 0.7994 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9664.001 | 0.0100 | -0.9937 | 0.7994 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7898.001 | 0.9206 | 0.8704 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7898.001 | 1.0523 | 1.0843 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7898.001 | 0.9378 | 0.8985 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7898.001 | 0.8625 | 0.7740 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7898.001 | 0.4156 | -0.0184 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7898.001 | 0.3349 | -0.1760 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7898.001 | 0.3904 | -0.0669 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7898.001 | 0.4104 | -0.0283 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7898.001 | 0.3181 | -0.2097 | 1.2337 | |
| MDA-MB-436 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7899.001 | 1.0832 | 1.0797 | 2.0444 |