Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7896.001 | 0.4682 | 0.0578 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7896.001 | 0.5277 | 0.1694 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7896.001 | 0.5704 | 0.2484 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7896.001 | 0.3479 | -0.1757 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9648.001 | 0.9880 | 0.9621 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9648.001 | 0.9853 | 0.9536 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9648.001 | 1.0044 | 1.0139 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9648.001 | 0.9697 | 0.9044 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9648.001 | 0.5048 | -0.3256 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 9648.001 | 0.5150 | -0.3037 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 9648.001 | 0.5213 | -0.2902 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 9648.001 | 0.5617 | -0.2006 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 9648.001 | 0.4554 | -0.4274 | 0.6289 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10095.001 | 0.9651 | 0.9230 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10095.001 | 0.9666 | 0.9262 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10095.001 | 0.9938 | 0.9862 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 10095.001 | 0.6304 | 0.2012 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 10095.001 | 0.5305 | -0.0074 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 10095.001 | 0.5324 | -0.0035 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 10095.001 | 0.6082 | 0.1545 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 10095.001 | 0.5865 | 0.1089 | 0.9049 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 10095.001 | 0.0402 | -0.9427 | 0.9049 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7897.001 | 0.9517 | 0.8716 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7897.001 | 1.0100 | 1.0268 | 0.7466 | |
| MDA-MB-415 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7897.001 | 1.0245 | 1.0659 | 0.7466 |