Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7892.001 | 0.4554 | 0.4832 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7892.001 | 0.1289 | -0.0818 | 2.6314 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7893.001 | 0.9628 | 0.9674 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7893.001 | 0.9132 | 0.9228 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7893.001 | 1.0134 | 1.0116 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7893.001 | 0.9391 | 0.9462 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7893.001 | 0.5008 | 0.4816 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7893.001 | 0.5420 | 0.5332 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7893.001 | 0.6096 | 0.6134 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7893.001 | 0.5488 | 0.5415 | 2.3044 | |
| MDA-MB-231 | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7893.001 | 0.3426 | 0.2564 | 2.3044 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7894.001 | 0.9557 | 0.8853 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7894.001 | 1.0113 | 1.0296 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7894.001 | 0.6876 | 0.2280 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7894.001 | 0.5190 | -0.1488 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7894.001 | 0.5295 | -0.1262 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.267 | uM | 7894.001 | 0.5589 | -0.0625 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 1.33 | uM | 7894.001 | 0.6454 | 0.1307 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 6.67 | uM | 7894.001 | 0.6354 | 0.1080 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 33.3 | uM | 7894.001 | 0.4495 | -0.2941 | 0.7678 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7896.001 | 1.0192 | 1.0322 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7896.001 | 1.0364 | 1.0610 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7896.001 | 0.4929 | 0.1044 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7896.001 | 0.4428 | 0.0093 | 1.1912 | |
| MDA-MB-361 | HER2amp | Luminal | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7896.001 | 0.4235 | -0.0278 | 1.1912 |