Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7863.001 | 0.2999 | 0.0065 | 1.7540 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7863.001 | 0.3334 | 0.0692 | 1.7540 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7863.001 | 0.3714 | 0.1371 | 1.7540 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7863.001 | 0.2742 | -0.0437 | 1.7540 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 7864.001 | 0.8829 | 0.8404 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 7864.001 | 1.0347 | 1.0461 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 7864.001 | 0.8911 | 0.8518 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 7864.001 | 0.8990 | 0.8628 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 7864.001 | 0.3342 | -0.0381 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 7864.001 | 0.3066 | -0.0917 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 7864.001 | 0.3355 | -0.0355 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 7864.001 | 0.4128 | 0.1078 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 7864.001 | 0.1990 | -0.3195 | 1.4976 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 9511.001 | 1.0439 | 1.0749 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.000427 | uM | 9511.001 | 1.0185 | 1.0315 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.00213 | uM | 9511.001 | 1.0458 | 1.0781 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0107 | uM | 9511.001 | 0.8291 | 0.7039 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.0533 | uM | 9511.001 | 0.3170 | -0.2509 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 0.267 | uM | 9511.001 | 0.2982 | -0.2891 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 1.33 | uM | 9511.001 | 0.3602 | -0.1644 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 6.67 | uM | 9511.001 | 0.4263 | -0.0351 | 1.1698 | |
| Hs 578T | TNBC | Basal B | GSK461364 | PLK1 | PLK | 33.3 | uM | 9511.001 | 0.0169 | -0.9389 | 1.1698 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.0000853 | uM | 10264.001 | 1.0194 | 1.0251 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.000427 | uM | 10264.001 | 1.0242 | 1.0314 | 1.5356 | |
| LY2 | HR+ | Luminal | GSK461364 | PLK1 | PLK | 0.00213 | uM | 10264.001 | 0.9514 | 0.9362 | 1.5356 |