Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7532.098 | 0.9344 | 0.8149 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7532.098 | 0.8786 | 0.6620 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7532.098 | 0.8913 | 0.6966 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7532.098 | 0.7712 | 0.3793 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7532.098 | 0.0300 | -0.9867 | 0.6992 | |
| SUM185PE | TNBC | Luminal | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7532.098 | 0.0100 | -0.9972 | 0.6992 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7533.091 | 1.0159 | 1.0422 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7533.091 | 1.0507 | 1.1355 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7533.091 | 0.9860 | 0.9631 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7533.091 | 1.0520 | 1.1389 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7533.091 | 1.0363 | 1.0969 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7533.091 | 1.0057 | 1.0150 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7533.091 | 1.0134 | 1.0356 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7533.091 | 1.1354 | 1.3666 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 133 | uM | 7533.091 | 0.3757 | -0.4535 | 0.7547 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7533.098 | 1.0150 | 1.0351 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7533.098 | 1.1104 | 1.2608 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7533.098 | 1.1338 | 1.3167 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7533.098 | 1.0670 | 1.1576 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7533.098 | 1.0660 | 1.1554 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7533.098 | 1.1084 | 1.2560 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7533.098 | 1.0056 | 1.0131 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7533.098 | 0.7659 | 0.4638 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7533.098 | 0.0447 | -0.9473 | 0.8545 | |
| SUM225CWN | HER2amp | Basal A | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 7534.071 | 1.0421 | 1.0778 | 1.0807 |