Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7486.098 | 1.0070 | 1.0152 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7486.098 | 1.1147 | 1.2516 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7486.098 | 1.1151 | 1.2525 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7486.098 | 0.9920 | 0.9824 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7486.098 | 0.8534 | 0.6824 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7486.098 | 0.3751 | -0.3140 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7486.098 | 0.1262 | -0.7910 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7486.098 | 0.1161 | -0.8091 | 0.9165 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7487.09 | 1.0186 | 1.0243 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7487.09 | 1.0447 | 1.0582 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7487.09 | 1.0257 | 1.0337 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7487.09 | 1.0569 | 1.0740 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7487.09 | 0.9005 | 0.8670 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7487.09 | 0.3197 | -0.0543 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7487.09 | 0.1804 | -0.3505 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7487.09 | 0.1430 | -0.4426 | 1.5226 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 133 | uM | 7487.09 | 0.0839 | -0.6071 | 1.5226 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7489.09 | 1.0471 | 1.0470 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7489.09 | 1.0696 | 1.0692 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7489.09 | 0.9851 | 0.9849 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7489.09 | 1.0757 | 1.0751 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7489.09 | 0.9129 | 0.9099 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7489.09 | 0.6538 | 0.6135 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7489.09 | 0.2825 | 0.0559 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7489.09 | 0.3767 | 0.2212 | 1.9790 |