Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7485.092 | 1.0465 | 1.0251 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7485.092 | 0.8879 | 0.9357 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7485.092 | 0.5383 | 0.6872 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7485.092 | 0.3112 | 0.4514 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7485.092 | 0.0782 | -0.0068 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7485.092 | 0.0246 | -0.2772 | 3.6408 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7485.098 | 1.0016 | 1.0009 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7485.098 | 1.0189 | 1.0112 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7485.098 | 1.0037 | 1.0022 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7485.098 | 0.9919 | 0.9952 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7485.098 | 0.8644 | 0.9154 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7485.098 | 0.4290 | 0.5562 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7485.098 | 0.2326 | 0.2979 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7485.098 | 0.0299 | -0.2936 | 3.3725 | |
| MCF 10A | NM | Basal B | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7485.098 | 0.0110 | -0.4745 | 3.3725 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7486.092 | 1.0701 | 1.1239 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.000853 | uM | 7486.092 | 1.0740 | 1.1309 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.00427 | uM | 7486.092 | 0.9617 | 0.9319 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.0213 | uM | 7486.092 | 1.0252 | 1.0446 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.107 | uM | 7486.092 | 1.0035 | 1.0062 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.533 | uM | 7486.092 | 0.4920 | 0.0657 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 2.67 | uM | 7486.092 | 0.4487 | -0.0181 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 13.3 | uM | 7486.092 | 0.4328 | -0.0489 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 66.7 | uM | 7486.092 | 0.3980 | -0.1173 | 1.1266 | |
| MCF 10F | NM | - | GSK1838705A | IGF1R | RTK | 0.000171 | uM | 7486.098 | 1.0348 | 1.0760 | 0.9165 |