Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 133 | uM | 7489.09 | 0.2546 | 0.0018 | 1.9790 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7490.091 | 1.0113 | 1.0088 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7490.091 | 0.9284 | 0.9427 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7490.091 | 0.9648 | 0.9721 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7490.091 | 0.9744 | 0.9798 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7490.091 | 0.9332 | 0.9466 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7490.091 | 0.6456 | 0.6851 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 5.33 | uM | 7490.091 | 0.5613 | 0.5953 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 26.7 | uM | 7490.091 | 0.0232 | -0.5417 | 2.5547 | |
| MCF12A | NM | Basal B | GSK1838705A | IGF1R | RTK | 133 | uM | 7490.091 | 0.4325 | 0.4406 | 2.5547 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000307 | uM | 7492.071 | 1.0378 | 1.0481 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00154 | uM | 7492.071 | 0.9739 | 0.9664 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00768 | uM | 7492.071 | 0.9186 | 0.8942 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0384 | uM | 7492.071 | 0.9558 | 0.9430 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.192 | uM | 7492.071 | 0.9471 | 0.9317 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.96 | uM | 7492.071 | 0.6542 | 0.5245 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 4.8 | uM | 7492.071 | 0.4960 | 0.2769 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 24 | uM | 7492.071 | 0.2030 | -0.2790 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 120 | uM | 7492.071 | 0.5290 | 0.3307 | 1.5629 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.000341 | uM | 7492.091 | 1.0447 | 1.0610 | 1.4539 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00171 | uM | 7492.091 | 1.0199 | 1.0273 | 1.4539 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.00853 | uM | 7492.091 | 0.9823 | 0.9756 | 1.4539 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.0427 | uM | 7492.091 | 1.0140 | 1.0193 | 1.4539 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 0.213 | uM | 7492.091 | 0.9372 | 0.9127 | 1.4539 | |
| MCF7 | HR+ | Luminal | GSK1838705A | IGF1R | RTK | 1.07 | uM | 7492.091 | 0.6312 | 0.4574 | 1.4539 |