Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7443.067 | 0.8137 | 0.6387 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7443.067 | 0.0067 | -0.9841 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7444.067 | 1.0403 | 1.1099 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7444.067 | 1.0877 | 1.2413 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7444.067 | 1.0717 | 1.1966 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7444.067 | 1.0654 | 1.1791 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7444.067 | 0.7657 | 0.3931 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7444.067 | 0.6903 | 0.2106 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7444.067 | 0.6719 | 0.1670 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7444.067 | 0.6086 | 0.0205 | 0.7382 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7444.067 | 0.0028 | -0.9993 | 0.7382 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7447.067 | 1.0066 | 1.0084 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7447.067 | 1.1012 | 1.1272 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7447.067 | 1.0024 | 1.0030 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7447.067 | 1.0731 | 1.0923 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7447.067 | 0.5679 | 0.3928 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.267 | uM | 7447.067 | 0.5025 | 0.2879 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 1.33 | uM | 7447.067 | 0.5165 | 0.3108 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 6.67 | uM | 7447.067 | 0.3608 | 0.0420 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 33.3 | uM | 7447.067 | 0.0041 | -0.9405 | 1.5637 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7448.067 | 0.9825 | 0.9877 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7448.067 | 1.0073 | 1.0051 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7448.067 | 0.9791 | 0.9852 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7448.067 | 0.9398 | 0.9568 | 2.8462 | |
| HCC1569 | HER2amp | Basal A | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7448.067 | 0.5711 | 0.6427 | 2.8462 |