Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7441.067 | 0.9765 | 0.9431 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7441.067 | 1.0132 | 1.0320 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7441.067 | 1.0164 | 1.0400 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7441.067 | 1.0727 | 1.1779 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7441.067 | 0.9392 | 0.8532 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7441.067 | 0.7952 | 0.5142 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7441.067 | 0.7648 | 0.4441 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7441.067 | 0.7797 | 0.4782 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7441.067 | 0.0071 | -0.9951 | 0.8233 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7442.067 | 0.9784 | 0.9526 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7442.067 | 0.9577 | 0.9075 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7442.067 | 0.9632 | 0.9196 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7442.067 | 0.9543 | 0.9002 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7442.067 | 0.7566 | 0.4734 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7442.067 | 0.6821 | 0.3150 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7442.067 | 0.7036 | 0.3607 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 6.67 | uM | 7442.067 | 0.6864 | 0.3242 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 33.3 | uM | 7442.067 | 0.0100 | -0.9871 | 0.9126 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0000853 | uM | 7443.067 | 0.9556 | 0.9141 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.000427 | uM | 7443.067 | 0.9924 | 0.9852 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.00213 | uM | 7443.067 | 0.9755 | 0.9526 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0107 | uM | 7443.067 | 0.9532 | 0.9095 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.0533 | uM | 7443.067 | 0.8748 | 0.7575 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 0.267 | uM | 7443.067 | 0.8735 | 0.7548 | 1.0344 | |
| HCC1428 | HR+ | Luminal | Ispinesib | KSP | Kinesin | 1.33 | uM | 7443.067 | 0.8064 | 0.6243 | 1.0344 |