Growth rate-corrected (GR) dose-response metrics across a panel of 71 breast cancer cell lines treated with a library of small molecule and antibody perturbagens. Dataset 1 of 4: Relative cell counts and normalized growth rate inhibition values across technical replicates. - Dataset (ID:20268)
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| Cell | Clinical Subtype | Transcriptional Subtype | Small Molecule | Antibody | Perturbagen Target | Perturbagen Class | Perturbagen Concentration | Perturbagen Conc Unit | Biological Replicate ID | Relative Cell Count | Normalized Growth Rate Inhibition Value | Nominal Division Rate |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 0.4 | uM | 12192.161 | 1.0899 | 1.3353 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 2 | uM | 12192.161 | 1.0153 | 1.0553 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 10 | uM | 12192.161 | 1.0629 | 1.2322 | 0.5555 | |
| HCC2185 | TNBC | Luminal | L-779450 | BRAF | MAPK | 50 | uM | 12192.161 | 0.6115 | -0.1748 | 0.5555 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10577.137 | 1.0328 | 1.0681 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10577.137 | 0.9889 | 0.9770 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10577.137 | 1.0090 | 1.0187 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10577.137 | 1.0498 | 1.1033 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10577.137 | 1.0121 | 1.0251 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10577.137 | 0.9677 | 0.9330 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10577.137 | 0.9901 | 0.9795 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10577.137 | 0.9848 | 0.9684 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10577.137 | 0.9121 | 0.8182 | 0.9653 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10937.149 | 1.0334 | 1.0493 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.000427 | uM | 10937.149 | 1.0388 | 1.0572 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.00213 | uM | 10937.149 | 1.0114 | 1.0168 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0107 | uM | 10937.149 | 1.0872 | 1.1275 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.0533 | uM | 10937.149 | 1.0211 | 1.0311 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 0.267 | uM | 10937.149 | 1.0469 | 1.0689 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 1.33 | uM | 10937.149 | 0.9827 | 0.9743 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 6.67 | uM | 10937.149 | 1.0926 | 1.1354 | 1.3519 | |
| HCC3153 | TNBC | Basal A | L-779450 | BRAF | MAPK | 33.3 | uM | 10937.149 | 0.8241 | 0.7333 | 1.3519 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.0000853 | uM | 10578.137 | 1.0033 | 1.0036 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.000427 | uM | 10578.137 | 0.8692 | 0.8523 | 1.8268 | |
| HCC38 | TNBC | Basal B | L-779450 | BRAF | MAPK | 0.00213 | uM | 10578.137 | 0.9681 | 0.9648 | 1.8268 |