Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
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| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF 10A | Linsitinib | 9 | 2500.00 | 4.9244 | 1.4819 | 0.3478 | 0.3390 | 0.9438 | 0.8015 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9711 | 29.885 | 3.3552 | 0.4919 | 0.4088 | 0.7781 | 0.1356 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9671 |
| MCF 10A | Linsitinib | 9 | 5000.00 | inf | 1.7371 | 0.5857 | 0.5900 | 1.0484 | 0.8880 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9773 | inf | 2.3651 | 0.6046 | 0.5874 | 0.9453 | 0.1017 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9745 |
| MCF 10A | 17-AAG | 9 | 156.25 | 0.0036 | 0.0033 | 0.1364 | 0.1550 | 3.7215 | 0.5414 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9889 | 0.0037 | 0.004 | -0.1057 | -0.0876 | 2.4085 | 0.5688 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9928 |
| MCF 10A | 17-AAG | 9 | 312.50 | 0.0064 | 0.0061 | 0.0829 | 0.0842 | 4.0254 | 0.5862 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9955 | 0.007 | 0.0074 | -0.0771 | -0.0787 | 3.4303 | 0.4715 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9934 |
| MCF 10A | 17-AAG | 9 | 625.00 | 0.0076 | 0.0073 | 0.0428 | 0.0470 | 2.8939 | 0.5897 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9957 | 0.0097 | 0.0101 | -0.0915 | -0.0603 | 3.0057 | 0.4208 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9959 |
| MCF 10A | 17-AAG | 9 | 1250.00 | 0.0107 | 0.0104 | 0.0449 | 0.0454 | 3.2996 | 0.6323 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9953 | 0.0132 | 0.0136 | -0.0497 | -0.0496 | 3.1343 | 0.3776 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9979 |
| MCF 10A | 17-AAG | 9 | 2500.00 | 0.0175 | 0.0167 | 0.0638 | 0.0651 | 3.2298 | 0.6760 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9996 | 0.0212 | 0.022 | -0.0662 | -0.0612 | 3.0246 | 0.3356 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9999 |
| MCF 10A | 17-AAG | 9 | 5000.00 | 0.036 | 0.0323 | 0.1357 | 0.1408 | 3.0233 | 0.7700 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.999 | 0.0363 | 0.0394 | -0.1213 | -0.1215 | 2.6826 | 0.2735 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9995 |