Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF 10A Linsitinib 8 1250.00
1.2211
0.8253
 0.1802 0.2187 1.4685 0.7235
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.991
3.6609
1.3748
 0.3171 0.3515 1.2398 0.1916
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9812
MCF 10A Linsitinib 8 2500.00
2.9308
1.3492
 0.2956 0.3433 1.4958 0.8114
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9812
7.4873
2.2558
 0.3698 0.3755 1.1586 0.1486
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9742
MCF 10A Linsitinib 8 5000.00
inf
2.2845
 0.5483 0.5359 1.0321 0.8902
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.976
inf
3.6286
 0.6408 0.5936 0.9128 0.0819
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9749
MCF 10A 17-AAG 8 156.25
0.0061
0.0055
 0.1501 0.1502 3.0065 0.6120
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9911
0.0086
0.007
 0.2284 0.2272 3.0221 0.3361
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.983
MCF 10A 17-AAG 8 312.50
0.0039
0.0036
 0.0928 0.0699 1.8458 0.5072
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9923
0.0051
0.0052
 0.0208 -0.0230 2.0818 0.5013
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9868
MCF 10A 17-AAG 8 625.00
0.0061
0.0059
 0.0464 0.0464 3.3555 0.5517
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9976
0.0081
0.0083
 -0.0477 -0.0477 3.2182 0.4536
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9982
MCF 10A 17-AAG 8 1250.00
0.0095
0.0093
 0.0425 0.0474 4.2812 0.6083
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9972
0.0118
0.0122
 -0.0686 -0.0564 3.2017 0.3980
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9991
MCF 10A 17-AAG 8 2500.00
0.0149
0.0141
 0.0808 0.0802 2.9692 0.6642
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9989
0.0172
0.0182
 -0.0837 -0.0854 2.7890 0.3653
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9997
MCF 10A 17-AAG 8 5000.00
0.0356
0.0301
 0.1778 0.1717 2.4740 0.7748
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9986
0.0417
0.0372
 0.1319 0.1255 2.5236 0.2181
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9994
MCF 10A Lapatinib 9 156.25
3.3184
3.1569
 0.1133 0.1104 5.0000 0.8985
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9462
3.2861
3.4912
 -0.1706 -0.1767 4.9992 0.1273
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9648
MCF 10A Lapatinib 9 312.50
3.3825
3.2839
 0.0724 0.0688 5.0000 0.9019
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9737
3.5948
3.7643
 -0.1210 -0.1295 5.0000 0.1029
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9857
MCF 10A Lapatinib 9 625.00
2.9012
2.9012
 0.0593 0.0000 2.0135 0.8662
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9856
4.1981
6.2986
 -0.0167 -0.4854 1.6724 0.1076
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9889
MCF 10A Lapatinib 9 1250.00
2.9956
2.9956
 0.0594 0.0000 2.0890 0.8858
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9838
4.316
6.0938
 -0.0030 -0.4203 1.7686 0.1025
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9935
MCF 10A Lapatinib 9 2500.00
3.5541
3.5541
 0.1045 0.0000 2.0067 0.8687
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9994
4.7842
6.8317
 0.0616 -0.4247 1.7258 0.1103
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9999
MCF 10A Lapatinib 9 5000.00
5.4916
5.4916
 0.2618 0.0000 1.6362 0.8911
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9866
5.6428
12.3465
 0.1432 -1.0000 1.4031 0.1103
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
MCF 10A Erlotinib 9 156.25
0.5395
0.474
 0.1867 0.2063 4.1113 0.6808
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9921
0.521
0.506
 0.0074 0.0507 3.6691 0.3843
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9923
MCF 10A Erlotinib 9 312.50
0.4473
0.4198
 0.1121 0.1214 4.3733 0.6321
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9961
0.508
0.4997
 0.0070 0.0305 3.8205 0.3953
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.996
MCF 10A Erlotinib 9 625.00
0.3562
0.3435
 0.0722 0.0834 5.0000 0.5992
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9948
0.4872
0.4701
 0.0360 0.0513 3.0363 0.3902
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.997
MCF 10A Erlotinib 9 1250.00
0.3509
0.337
 0.0624 0.0719 3.8413 0.5825
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9969
0.4762
0.4597
 0.0282 0.0481 2.8707 0.3983
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9976
MCF 10A Erlotinib 9 2500.00
0.3955
0.3674
 0.0988 0.1046 3.1831 0.5916
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9996
0.4974
0.4729
 0.0543 0.0679 2.8878 0.3984
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9997
MCF 10A Erlotinib 9 5000.00
0.5422
0.4267
 0.2130 0.2259 2.5085 0.6550
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9986
0.5403
0.502
 0.0575 0.0827 2.4574 0.3899
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9988
MCF 10A Linsitinib 9 156.25
0.9682
0.8438
 0.1549 0.2487 5.0000 0.7385
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9736
0.9652
0.9132
 -0.0611 0.1210 4.9999 0.2953
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9572
MCF 10A Linsitinib 9 312.50
0.9605
0.8501
 0.1251 0.2285 5.0000 0.7341
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9747
1.3095
1.0142
 0.0449 0.1997 1.9948 0.2473
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9502
MCF 10A Linsitinib 9 625.00
0.9222
0.6667
 0.1294 0.2245 1.8379 0.7125
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9703
3.1717
1.8279
 0.1914 0.1974 0.9112 0.2147
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9488
MCF 10A Linsitinib 9 1250.00
1.4382
0.9978
 0.1698 0.2319 1.7047 0.7615
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9835
4.7896
1.9839
 0.2973 0.3184 1.1491 0.1655
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9679