Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
Hs 578T Linsitinib 10 156.25
23.7421
23.742
 0.6983 0.0000 5.0000 1.0242
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8152
22.7773
28.3743
 0.7010 -1.0000 5.0000 -0.0224
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8137
Hs 578T Linsitinib 10 312.50
inf
17.6822
 0.7375 0.5168 1.2136 0.9723
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8789
inf
17.5381
 0.7886 0.6138 1.2920 0.0176
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8487
Hs 578T Linsitinib 10 625.00
29.2056
26.8077
 0.6872 0.0869 2.2286 0.9965
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9248
34.061
28.4029
 0.7434 0.1705 2.2951 0.0037
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9333
Hs 578T Linsitinib 10 1250.00
inf
11.0784
 0.8408 0.8325 4.9978 1.0060
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.798
inf
11.204
 0.8600 0.8524 4.9937 -0.0050
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7924
Hs 578T Linsitinib 10 2500.00
inf
31.0444
 0.9304 0.5742 3.7178 1.0067
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.5323
inf
26.1338
 0.9038 0.6275 3.9457 -0.0091
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.535
Hs 578T Linsitinib 10 5000.00
inf
inf
 1.0243 1.0243 0.0000 1.0083
flat fit: x = Einf
-0.3627
inf
inf
 1.0500 1.0500 0.0000 -0.0065
flat fit: x = Einf
-0.1135
Hs 578T Omipalisib 10 156.25
0.0847
0.0285
 0.2842 0.3718 1.2502 0.5837
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.95
0.0208
0.0217
 -0.2272 -0.0241 1.2382 0.7125
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9196
Hs 578T Omipalisib 10 312.50
0.056
0.0273
 0.2568 0.2519 0.9751 0.4953
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9751
0.0249
0.0304
 -0.0698 -0.0892 0.8303 0.7172
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9839
Hs 578T Omipalisib 10 625.00
0.0471
0.0245
 0.2167 0.2299 0.9422 0.4776
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9902
0.0165
0.0248
 -0.1783 -0.1728 0.7314 0.7814
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9878
Hs 578T Omipalisib 10 1250.00
0.0423
0.0184
 0.2450 0.2585 0.8770 0.4761
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9927
0.0121
0.0164
 -0.1248 -0.1163 0.6852 0.7872
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9893
Hs 578T Omipalisib 10 2500.00
0.0853
0.0274
 0.2498 0.2485 0.6052 0.5114
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9949
0.0139
0.0281
 -0.2082 -0.2246 0.5290 0.7841
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
Hs 578T Omipalisib 10 5000.00
1.0392
0.163
 0.3820 0.2592 0.3945 0.6414
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9917
0.0621
0.3286
 -0.2082 -0.5021 0.4174 0.6403
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.984
Hs 578T 17-AAG 10 156.25
0.0098
0.008
 0.1934 0.2080 2.6944 0.3539
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9987
0.009
0.0092
 -0.0465 -0.0189 2.1357 0.8138
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9962
Hs 578T 17-AAG 10 312.50
0.0087
0.008
 0.1794 0.1838 5.0000 0.3298
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9962
0.0092
0.0089
 0.0702 0.0786 4.9784 0.7445
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9952
Hs 578T 17-AAG 10 625.00
0.0097
0.0087
 0.1372 0.1763 4.0979 0.3356
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.995
0.0103
0.0098
 -0.0145 0.0720 3.2542 0.7285
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9888
Hs 578T 17-AAG 10 1250.00
0.0215
0.0187
 0.2385 0.2507 5.0000 0.4583
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9983
0.0214
0.0203
 0.0989 0.1227 4.9999 0.6294
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9972
Hs 578T 17-AAG 10 2500.00
0.0444
0.0307
 0.4047 0.4213 5.0000 0.6183
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9975
0.0331
0.0315
 0.0748 0.1044 4.6221 0.5869
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9972
Hs 578T 17-AAG 10 5000.00
inf
0.0435
 0.7155 0.7423 1.6344 0.8401
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9744
0.0528
0.0407
 0.0972 0.1695 1.6032 0.5221
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9749
Hs 578T Palbociclib 11 156.25
1.0054
0.2812
 0.3924 0.4245 1.4841 0.7335
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9591
0.3259
0.2543
 0.1036 0.1768 1.7601 0.3925
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9735
Hs 578T Palbociclib 11 312.50
0.9466
0.4587
 0.3502 0.4256 2.6300 0.7804
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9741
0.6839
0.5351
 0.1069 0.2346 2.5829 0.2853
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9716
Hs 578T Palbociclib 11 625.00
0.9225
0.3581
 0.2986 0.3417 1.2153 0.7017
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9811
0.4559
0.3503
 0.0495 0.1277 1.1195 0.3949
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9663
Hs 578T Palbociclib 11 1250.00
1.1845
0.4074
 0.3861 0.4040 1.5462 0.7447
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9804
0.6112
0.4468
 0.1771 0.2192 1.8410 0.3241
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9877
Hs 578T Palbociclib 11 2500.00
2.5994
0.2906
 0.4573 0.4497 1.0479 0.7307
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9841
0.4751
0.3196
 0.1814 0.1689 1.0394 0.3975
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.984
Hs 578T Palbociclib 11 5000.00
inf
0.2178
 0.5856 0.5710 1.0286 0.7712
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9799
0.294
0.1426
 0.2525 0.2177 0.7904 0.4477
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9699
Hs 578T Nilotinib 11 156.25
inf
inf
 1.0500 1.0500 0.0000 1.0057
flat fit: x = Einf
-0.0376
inf
inf
 1.0500 1.0500 0.0000 0.0353
flat fit: x = Einf
0.0442