Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
Hs 578T Nilotinib 11 312.50
inf
inf
 1.0500 1.0500 0.0000 1.0420
flat fit: x = Einf
-5.2565
inf
inf
 1.0500 1.0500 0.0000 -0.0363
flat fit: x = Einf
-2.0404
Hs 578T Nilotinib 11 625.00
inf
inf
 0.7792 0.7792 0.0000 0.9827
flat fit: x = Einf
0.3454
inf
inf
 0.8120 0.8120 0.0000 0.0117
flat fit: x = Einf
0.2286
Hs 578T Nilotinib 11 1250.00
inf
4.608
 0.5163 0.6047 5.0000 0.9542
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9012
inf
5.0334
 0.3935 0.5666 5.0000 0.0431
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7972
Hs 578T Nilotinib 11 2500.00
8.7505
5.6565
 0.4584 0.4436 5.0000 0.9402
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9791
6.261
5.7783
 0.1848 0.1653 5.0000 0.0938
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9878
Hs 578T Nilotinib 11 5000.00
9.9994
5.1878
 0.4470 0.4415 3.2687 0.9249
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9915
7.078
7.2854
 -0.0658 -0.0777 5.0000 0.1017
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9909
Hs 578T Taxol 11 156.25
0.0055
0.0022
 0.3561 0.3434 1.2654 0.5418
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9429
0.0034
0.0033
 0.0328 0.0065 1.3379 0.6592
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9329
Hs 578T Taxol 11 312.50
0.0053
0.0028
 0.2779 0.3258 1.6543 0.5490
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9802
0.0041
0.0038
 -0.0318 0.0739 2.1989 0.5866
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9648
Hs 578T Taxol 11 625.00
0.0025
0.0017
 0.2067 0.2611 1.9157 0.4642
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9848
0.002
0.0022
 -0.1356 -0.0482 1.4268 0.7278
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9673
Hs 578T Taxol 11 1250.00
0.0023
0.0015
 0.2428 0.2754 1.9895 0.4638
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9947
0.0017
0.0018
 -0.0923 -0.0345 1.7019 0.7506
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9926
Hs 578T Taxol 11 2500.00
0.0047
0.0031
 0.3014 0.3277 2.4848 0.5622
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9918
0.0032
0.0034
 -0.1044 -0.0657 2.0413 0.6826
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
Hs 578T Taxol 11 5000.00
0.0292
0.0061
 0.4522 0.4772 1.9821 0.7000
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
0.0084
0.0084
 -0.0763 0.0078 5.0000 0.5318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9788
Hs 578T Omipalisib 11 156.25
0.0964
0.0309
 0.3097 0.2988 0.8010 0.5475
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9179
0.0246
0.0301
 -0.0513 -0.0763 0.7131 0.6939
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9126
Hs 578T Omipalisib 11 312.50
0.0506
0.0227
 0.2557 0.2749 0.9924 0.5031
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9739
0.0225
0.025
 -0.0752 -0.0483 0.8774 0.7057
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9794
Hs 578T Omipalisib 11 625.00
0.0321
0.0167
 0.1707 0.2226 0.9000 0.4451
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9869
0.0144
0.0208
 -0.2155 -0.1422 0.6795 0.7755
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9787
Hs 578T Omipalisib 11 1250.00
0.04
0.0187
 0.1956 0.2169 0.7494 0.4530
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9903
0.0143
0.0232
 -0.1946 -0.1750 0.6148 0.7841
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
Hs 578T Omipalisib 11 2500.00
0.07
0.0202
 0.2498 0.2804 0.6627 0.5084
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9824
0.0129
0.0208
 -0.2117 -0.1623 0.5903 0.7827
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9748
Hs 578T Omipalisib 11 5000.00
1.3071
0.1398
 0.3973 0.2963 0.4016 0.6518
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9881
0.0708
0.2673
 -0.1738 -0.3939 0.4373 0.6136
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9845
MCF 10A NVP-TAE684 2 156.25
0.2198
0.1956
 0.0448 0.0878 1.6526 0.6130
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9859
0.3657
0.5028
 -0.1967 -0.1932 1.0256 0.3903
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.985
MCF 10A NVP-TAE684 2 312.50
0.2682
0.2464
 0.0419 0.0540 1.3479 0.6213
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9815
0.5175
0.8054
 -0.1850 -0.2901 1.0342 0.3654
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9846
MCF 10A NVP-TAE684 2 625.00
0.2465
0.2352
 0.0343 0.0265 1.1678 0.5928
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
0.5061
0.7905
 -0.1686 -0.2696 0.9671 0.3732
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9965
MCF 10A NVP-TAE684 2 1250.00
0.3799
0.374
 0.0432 0.0083 1.0640 0.6245
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9887
0.6453
0.9465
 -0.1455 -0.2348 1.0048 0.3449
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9936
MCF 10A NVP-TAE684 2 2500.00
0.5918
0.5365
 0.0944 0.0501 1.0760 0.6842
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9947
0.5939
1.044
 -0.2600 -0.3910 1.0240 0.3703
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9974
MCF 10A NVP-TAE684 2 5000.00
1.0521
0.7817
 0.2012 0.1131 0.8632 0.7329
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9894
0.2682
0.771
 -0.6027 -0.7682 0.8814 0.5318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9891
MCF 10A PLX-4720 2 156.25
22.1967
22.1965
 0.6247 0.0000 5.0000 1.0070
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8922
24.4822
25.1687
 0.7412 -0.0741 4.9994 -0.0107
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8199
MCF 10A PLX-4720 2 312.50
19.5454
16.7544
 0.4823 0.2673 4.9646 1.0034
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.937
22.939
21.0685
 0.6280 0.1592 4.5057 -0.0123
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.905