Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

 Full screen view
Filter results: >>>>
Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF 10A PLX-4720 2 625.00
14.5022
11.5466
 0.3798 0.3400 4.9995 0.9713
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9678
inf
12.3292
 0.5546 0.5149 5.0000 0.0110
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9537
MCF 10A PLX-4720 2 1250.00
18.8327
16.0279
 0.4564 0.2768 5.0000 0.9774
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9462
22.4188
22.2835
 0.6157 0.0125 4.1731 0.0104
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9422
MCF 10A PLX-4720 2 2500.00
inf
inf
 0.8861 0.8861 0.0000 1.0387
flat fit: x = Einf
0.272
inf
inf
 0.9015 0.9015 0.0000 -0.0368
flat fit: x = Einf
0.182
MCF 10A PLX-4720 2 5000.00
inf
inf
 1.0500 1.0500 0.0000 1.0447
flat fit: x = Einf
-18.1943
inf
inf
 1.0500 1.0500 0.0000 -0.0500
flat fit: x = Einf
-inf
MCF 10A Palbociclib 2 156.25
0.1237
0.1021
 0.0967 0.0687 0.7724 0.4389
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9176
0.1448
0.2039
 -0.1228 -0.1512 0.7718 0.6091
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9588
MCF 10A Palbociclib 2 312.50
0.1594
0.159
 0.0690 0.0010 0.6701 0.4440
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8795
0.2255
0.2679
 -0.1302 -0.1022 1.0788 0.5607
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9372
MCF 10A Palbociclib 2 625.00
0.1286
0.1286
 0.0845 0.0000 0.5445 0.4281
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9003
0.2782
0.4166
 0.0021 -0.1343 0.5888 0.5221
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9481
MCF 10A Palbociclib 2 1250.00
0.2478
0.1932
 0.0984 0.1145 1.0445 0.5302
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9934
0.4898
0.4492
 0.0280 0.0352 0.8448 0.4169
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9898
MCF 10A Palbociclib 2 2500.00
0.2755
0.1199
 0.2164 0.1920 0.5821 0.5371
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.988
0.2422
0.2969
 0.0264 -0.0567 0.5274 0.5123
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9908
MCF 10A Palbociclib 2 5000.00
0.4834
0.0784
 0.4261 0.4142 0.9686 0.6216
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9649
0.042
0.0726
 -0.3021 -0.3316 0.9292 0.8679
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9664
MCF 10A Nilotinib 2 156.25
6.2532
5.9521
 0.1177 0.1093 4.9999 0.9156
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9788
5.9768
5.7526
 0.0623 0.0870 4.9994 0.0912
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9756
MCF 10A Nilotinib 2 312.50
7.0541
6.7455
 0.1153 0.1002 5.0000 0.9199
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
7.8049
7.4949
 0.1020 0.0917 5.0000 0.0772
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9874
MCF 10A Nilotinib 2 625.00
8.7001
8.4479
 0.0818 0.0684 5.0000 0.9328
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
10.0294
9.941
 0.0506 0.0216 5.0000 0.0547
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9867
MCF 10A Nilotinib 2 1250.00
8.8828
8.607
 0.0873 0.0730 5.0000 0.9288
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9875
9.9774
9.9638
 0.0332 0.0034 5.0000 0.0666
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9918
MCF 10A Nilotinib 2 2500.00
12.3396
11.573
 0.1898 0.1372 5.0000 0.9807
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9745
12.0732
12.509
 -0.0012 -0.0970 5.0000 0.0260
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9826
MCF 10A Nilotinib 2 5000.00
16.3463
13.3592
 0.3978 0.3177 4.9999 1.0004
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9593
11.9821
13.3965
 -0.2103 -0.3735 5.0000 0.0351
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9885
MCF 10A Taxol 2 156.25
0.0011
0.001
 0.1173 0.1380 5.0000 0.3267
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9928
0.0012
0.0012
 -0.0507 -0.0058 3.4813 0.7622
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9832
MCF 10A Taxol 2 312.50
0.0012
0.0011
 0.0884 0.0959 2.5106 0.2981
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9912
0.0016
0.0017
 -0.0507 -0.0660 1.8108 0.7777
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9917
MCF 10A Taxol 2 625.00
0.0009
0.0009
 0.0735 0.0846 5.0000 0.2635
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9848
0.0013
0.0014
 -0.0326 -0.0417 1.9556 0.7814
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9843
MCF 10A Taxol 2 1250.00
0.0018
0.0017
 0.0642 0.0609 1.7212 0.3121
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9975
0.0025
0.0027
 -0.0761 -0.0769 1.8246 0.7361
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9955
MCF 10A Taxol 2 2500.00
0.0032
0.0028
 0.1227 0.1234 2.2804 0.4115
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9984
0.0031
0.0036
 -0.1955 -0.1888 2.3648 0.7690
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9981
MCF 10A Taxol 2 5000.00
0.0073
0.0055
 0.2859 0.2803 2.9061 0.5644
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9914
0.004
0.0052
 -0.5742 -0.5845 2.8799 0.9724
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9921
MCF 10A Omipalisib 2 156.25
0.0014
0.0014
 0.0147 0.0083 0.7354 0.1077
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9855
0.0023
0.0062
 -0.5311 -0.5261 0.7437 1.2242
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9721
MCF 10A Omipalisib 2 312.50
0.0007
0.0007
 0.0048 0.0000 0.6276 0.0873
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8472
0.0019
0.0054
 -0.6121 -0.5544 0.7097 1.2533
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9374
MCF 10A Omipalisib 2 625.00
0.0006
0.0006
 0.0057 0.0068 0.7440 0.0657
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9923
0.0016
0.0044
 -0.5276 -0.4835 0.6605 1.2185
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.947