Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
SK-BR-3 Erlotinib 7 5000.00
inf
5.728
 0.6003 0.5977 4.1212 0.9350
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.984
14.3196
5.8686
 0.4909 0.4872 4.1109 0.0823
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9847
SK-BR-3 Linsitinib 7 156.25
inf
inf
 0.8913 0.8913 0.0000 1.0200
flat fit: x = Einf
-0.1011
inf
inf
 0.8526 0.8526 0.0000 -0.0148
flat fit: x = Einf
0.0567
SK-BR-3 Linsitinib 7 312.50
inf
15.021
 0.7120 0.6430 4.9900 1.0098
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.88
15.1693
15.4998
 0.1740 -0.0569 5.0000 0.0297
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9668
SK-BR-3 Linsitinib 7 625.00
inf
11.4712
 0.6623 0.6138 3.4884 0.9972
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9092
12.5173
11.0022
 0.2684 0.2003 3.9664 0.0383
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9772
SK-BR-3 Linsitinib 7 1250.00
48.893
48.893
 0.6383 0.0000 0.7819 0.9318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8447
13.3297
56.1749
 0.3168 -1.0000 0.7637 0.1318
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8508
SK-BR-3 Linsitinib 7 2500.00
inf
1.8874
 0.6895 0.7090 1.1899 0.9342
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9144
8.3742
1.999
 0.3743 0.4010 1.1308 0.1406
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9348
SK-BR-3 Linsitinib 7 5000.00
inf
3.3662
 0.7633 0.7113 0.6977 0.9314
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9732
inf
4.5037
 0.7108 0.6229 0.6567 0.0826
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9744
SK-BR-3 17-AAG 7 156.25
inf
0.0041
 0.6507 0.7107 1.6711 0.7413
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.604
inf
0.0043
 0.5137 0.5928 1.4944 0.3602
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.6048
SK-BR-3 17-AAG 7 312.50
inf
0.0028
 0.5881 0.5980 1.6852 0.6333
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8866
0.003
0.0031
 -0.1098 -0.0810 5.0000 0.9907
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9361
SK-BR-3 17-AAG 7 625.00
inf
0.0026
 0.5137 0.5519 5.0000 0.5821
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9441
0.0027
0.0026
 -0.0429 0.0360 5.0000 0.8987
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9466
SK-BR-3 17-AAG 7 1250.00
0.0163
0.0051
 0.4204 0.4385 1.8104 0.5154
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9851
0.0049
0.0053
 -0.1030 -0.0688 1.8505 0.9198
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9845
SK-BR-3 17-AAG 7 2500.00
0.0891
0.0068
 0.4737 0.4830 1.3149 0.5733
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9898
0.0064
0.0068
 -0.0575 -0.0381 1.3322 0.8578
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9896
SK-BR-3 17-AAG 7 5000.00
inf
0.0108
 0.5848 0.5607 2.0754 0.6552
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9843
0.0285
0.011
 0.4685 0.4304 2.0828 0.4459
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9778
SK-BR-3 Lapatinib 8 156.25
inf
0.9707
 0.6286 0.6176 1.1365 0.9157
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9397
14.5868
1.1539
 0.5010 0.4669 1.0703 0.1165
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9587
SK-BR-3 Lapatinib 8 312.50
inf
0.4817
 0.5459 0.5720 1.2347 0.8602
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9045
0.3606
0.4621
 -0.2101 -0.1692 1.1751 0.4142
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9179
SK-BR-3 Lapatinib 8 625.00
3.4067
0.035
 0.4553 0.4922 0.9092 0.6769
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9629
0.04
0.0369
 -0.0326 0.0342 0.8915 0.6085
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9617
SK-BR-3 Lapatinib 8 1250.00
0.2306
0.0282
 0.4105 0.4311 0.9427 0.6224
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9852
0.0325
0.0312
 -0.0208 0.0182 0.9266 0.6401
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9837
SK-BR-3 Lapatinib 8 2500.00
inf
0.0236
 0.5009 0.5033 1.1005 0.6571
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9823
0.0297
0.0246
 0.0890 0.0937 1.1007 0.6214
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9817
SK-BR-3 Lapatinib 8 5000.00
inf
0.0274
 0.6214 0.6002 1.2193 0.7272
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9735
inf
0.03
 0.5434 0.5155 1.2513 0.3263
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9712
SK-BR-3 Erlotinib 8 156.25
inf
inf
 0.7498 0.7498 0.0000 1.0025
flat fit: x = Einf
0.2395
inf
inf
 0.6757 0.6757 0.0000 0.0034
flat fit: x = Einf
0.2852
SK-BR-3 Erlotinib 8 312.50
inf
inf
 0.8004 0.8004 0.0000 1.0130
flat fit: x = Einf
0.1445
inf
inf
 0.4426 0.4426 0.0000 0.0291
flat fit: x = Einf
0.3495
SK-BR-3 Erlotinib 8 625.00
inf
2.3966
 0.6126 0.5859 1.1381 0.9110
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9399
4.1534
2.5395
 0.2727 0.2046 1.0700 0.1835
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9627
SK-BR-3 Erlotinib 8 1250.00
15.7061
6.8235
 0.4788 0.2962 1.0762 0.8778
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9121
5.1618
7.2066
 0.1089 -0.2181 1.0846 0.2086
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9256
SK-BR-3 Erlotinib 8 2500.00
inf
4.0127
 0.5134 0.5139 3.4334 0.9175
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.984
4.3777
4.059
 0.1134 0.1133 3.4009 0.1551
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9887
SK-BR-3 Erlotinib 8 5000.00
inf
7.1425
 0.5579 0.5307 2.7310 0.9320
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9829
14.5421
7.5151
 0.4556 0.4175 2.7290 0.0804
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9861