Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Replicate | Seeding Density | IC50 | EC50 | Emax | Einf | IC Hill Coefficient | IC_AUC | IC Curve Fit | IC r2 | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC | GR Curve Fit | GR r2 |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Linsitinib | 8 | 156.25 | 46.3136 | 22.2213 | 0.8005 | 0.4813 | 4.4761 | 1.0111 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7292 | 24.0619 | 23.9551 | 0.6948 | 0.0099 | 4.4875 | 0.0036 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7825 |
| SK-BR-3 | Linsitinib | 8 | 312.50 | 29.16 | 21.8238 | 0.7554 | 0.3800 | 4.9241 | 1.0198 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7836 | 18.3512 | 22.8607 | 0.3167 | -1.0000 | 5.0000 | -0.0104 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9523 |
| SK-BR-3 | Linsitinib | 8 | 625.00 | 37.2116 | 24.5116 | 0.7216 | 0.2938 | 2.1213 | 0.9982 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8347 | 19.4615 | 34.3817 | 0.4798 | -0.9615 | 1.8848 | 0.0294 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9134 |
| SK-BR-3 | Linsitinib | 8 | 1250.00 | 33.7 | 33.7 | 0.5878 | 0.0000 | 0.8786 | 0.9424 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9281 | 12.9477 | 45.6592 | 0.3081 | -1.0000 | 0.8717 | 0.0965 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9433 |
| SK-BR-3 | Linsitinib | 8 | 2500.00 | 54.598 | 54.5886 | 0.6325 | 0.0001 | 0.6387 | 0.9294 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9457 | 12.3165 | 69.9717 | 0.3367 | -1.0000 | 0.6324 | 0.1263 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9459 |
| SK-BR-3 | Linsitinib | 8 | 5000.00 | inf | 2.4998 | 0.7530 | 0.7612 | 1.4176 | 0.9440 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9753 | inf | 2.761 | 0.7135 | 0.7175 | 1.3379 | 0.0635 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9737 |
| SK-BR-3 | 17-AAG | 8 | 156.25 | inf | 0.0052 | 0.7016 | 0.7142 | 4.9998 | 0.8595 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7185 | inf | 0.0049 | 0.6033 | 0.6175 | 5.0000 | 0.1966 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7037 |
| SK-BR-3 | 17-AAG | 8 | 312.50 | inf | 0.0078 | 0.6315 | 0.6356 | 3.4227 | 0.8427 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9353 | 0.0073 | 0.0072 | -0.0134 | 0.0176 | 3.3736 | 0.4517 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9484 |
| SK-BR-3 | 17-AAG | 8 | 625.00 | 0.0138 | 0.0058 | 0.3989 | 0.4288 | 2.2474 | 0.7285 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9759 | 0.0054 | 0.0058 | -0.1450 | -0.0864 | 2.1832 | 0.5189 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9832 |
| SK-BR-3 | 17-AAG | 8 | 1250.00 | 0.0163 | 0.0073 | 0.3853 | 0.4001 | 1.9804 | 0.7241 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.984 | 0.0073 | 0.0076 | -0.0664 | -0.0408 | 1.9257 | 0.4693 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.986 |
| SK-BR-3 | 17-AAG | 8 | 2500.00 | 0.0243 | 0.0076 | 0.4301 | 0.4458 | 1.9132 | 0.7657 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9935 | 0.0076 | 0.0078 | -0.0471 | -0.0182 | 1.8695 | 0.4306 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9958 |
| SK-BR-3 | 17-AAG | 8 | 5000.00 | inf | 0.0192 | 0.5269 | 0.5196 | 1.6160 | 0.8412 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9948 | 0.0576 | 0.0211 | 0.4110 | 0.3998 | 1.6017 | 0.1921 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9959 |
| SK-BR-3 | Lapatinib | 9 | 156.25 | 16.828 | 1.2472 | 0.4816 | 0.3733 | 0.5275 | 0.8233 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8215 | 0.1014 | 0.3913 | -0.5604 | -0.6295 | 0.6032 | 0.6141 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8844 |
| SK-BR-3 | Lapatinib | 9 | 312.50 | 2.2746 | 0.4033 | 0.3795 | 0.3227 | 0.5993 | 0.7432 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9457 | 0.0872 | 0.2675 | -0.4691 | -0.5330 | 0.6475 | 0.6364 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9614 |
| SK-BR-3 | Lapatinib | 9 | 625.00 | 0.4535 | 0.0438 | 0.3903 | 0.4599 | 1.0787 | 0.6735 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9687 | 0.0378 | 0.044 | -0.2262 | -0.0880 | 1.0679 | 0.6564 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9715 |
| SK-BR-3 | Lapatinib | 9 | 1250.00 | 0.1276 | 0.0298 | 0.3149 | 0.3707 | 0.9302 | 0.5892 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9823 | 0.0277 | 0.0342 | -0.2071 | -0.1035 | 0.8937 | 0.7021 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.98 |
| SK-BR-3 | Lapatinib | 9 | 2500.00 | 0.1185 | 0.0245 | 0.3702 | 0.4085 | 1.0779 | 0.5990 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9886 | 0.0206 | 0.0255 | -0.2023 | -0.1278 | 1.0674 | 0.7592 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9881 |
| SK-BR-3 | Lapatinib | 9 | 5000.00 | 0.5429 | 0.0487 | 0.4661 | 0.4569 | 1.0165 | 0.6689 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9932 | 0.0277 | 0.0433 | -0.2726 | -0.2906 | 1.0272 | 0.8033 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.993 |
| SK-BR-3 | Erlotinib | 9 | 156.25 | inf | inf | 0.6032 | 0.6032 | 0.0000 | 0.9433 | flat fit: x = Einf | 0.4594 | 0.8809 | 0.6454 | -0.2067 | 0.3945 | 5.0000 | 0.2563 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.527 |
| SK-BR-3 | Erlotinib | 9 | 312.50 | inf | inf | 0.5656 | 0.5656 | 0.0000 | 0.9624 | flat fit: x = Einf | 0.4325 | inf | inf | -0.0876 | -0.0876 | 0.0000 | 0.1408 | flat fit: x = Einf | 0.4757 |
| SK-BR-3 | Erlotinib | 9 | 625.00 | inf | 3.1561 | 0.5151 | 0.6267 | 5.0000 | 0.9356 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.861 | 3.6558 | 3.1813 | 0.0260 | 0.2505 | 5.0000 | 0.1583 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.8788 |
| SK-BR-3 | Erlotinib | 9 | 1250.00 | inf | 3.091 | 0.4663 | 0.5071 | 4.7085 | 0.9036 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9651 | 3.3952 | 3.138 | 0.0882 | 0.1627 | 5.0000 | 0.1761 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9751 |
| SK-BR-3 | Erlotinib | 9 | 2500.00 | 8.394 | 3.6905 | 0.4877 | 0.4913 | 4.9264 | 0.9275 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9835 | 3.7691 | 3.7115 | 0.0296 | 0.0365 | 4.9260 | 0.1490 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9924 |
| SK-BR-3 | Erlotinib | 9 | 5000.00 | 25.7418 | 5.7287 | 0.5094 | 0.4877 | 2.4636 | 0.9290 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9951 | 4.7111 | 5.4714 | -0.1819 | -0.2261 | 2.4938 | 0.1790 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.9972 |
| SK-BR-3 | Linsitinib | 9 | 156.25 | inf | 0.9102 | 0.7476 | 0.8316 | 5.0000 | 0.9692 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.7224 | 1.1719 | 0.809 | 0.0729 | 0.4216 | 5.0000 | 0.1678 | sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill) | 0.6955 |