Breast Cancer Cell Density: Imaging assay of the density- and context-dependence of small molecule perturbagen response in breast cancer cell lines. Dataset 3 of 3: Calculated dose-response metrics. - Dataset (ID:20258)

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Cell Small Molecule Replicate Seeding Density IC50 EC50 Emax Einf IC Hill Coefficient IC_AUC IC Curve Fit IC r2 GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC GR Curve Fit GR r2
MCF7 Taxol 1 312.50
0.0035
0.0012
 0.2945 0.3606 1.1730 0.5129
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.942
0.0012
0.0013
 -0.1548 -0.0314 1.1319 0.7704
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9429
MCF7 Taxol 1 625.00
0.0113
0.0019
 0.4205 0.4632 1.4557 0.6233
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9537
0.0012
0.0016
 -0.3666 -0.2756 1.4872 0.9204
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9688
MCF7 Taxol 1 1250.00
0.0036
0.0014
 0.3303 0.3921 1.6755 0.5508
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9688
0.0009
0.0012
 -0.5017 -0.3721 1.9234 1.0377
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9722
MCF7 Taxol 1 2500.00
0.0044
0.0022
 0.3561 0.3948 2.1797 0.5827
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9748
0.0018
0.0021
 -0.2606 -0.1909 2.0313 0.8321
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9788
MCF7 Taxol 1 5000.00
0.0065
0.0027
 0.3599 0.3739 1.5530 0.5780
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.982
0.0035
0.003
 0.0747 0.1011 1.5593 0.5950
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9839
MCF7 Omipalisib 1 156.25
0.009
0.0043
 0.3976 0.4456 2.9647 0.5133
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9704
0.0042
0.0042
 -0.1123 -0.0094 3.1275 0.8865
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9704
MCF7 Omipalisib 1 312.50
0.0114
0.0033
 0.3338 0.3466 0.9487 0.4345
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9834
0.0035
0.0039
 -0.0812 -0.0547 0.9578 0.8986
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9815
MCF7 Omipalisib 1 625.00
0.0443
0.0082
 0.3579 0.4079 0.9999 0.5352
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9508
0.0044
0.0072
 -0.4899 -0.3808 1.1514 1.1099
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9464
MCF7 Omipalisib 1 1250.00
0.0113
0.0041
 0.3383 0.3456 1.1539 0.4359
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9904
0.002
0.0036
 -0.4937 -0.4741 1.1677 1.2890
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9938
MCF7 Omipalisib 1 2500.00
0.0135
0.0054
 0.2947 0.3274 1.1646 0.4378
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9866
0.0035
0.0053
 -0.3892 -0.3204 1.2001 1.1077
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9888
MCF7 Omipalisib 1 5000.00
0.0126
0.0055
 0.3195 0.3504 1.4480 0.4514
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9928
0.0068
0.0063
 0.0011 0.0573 1.4268 0.7822
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9918
MCF7 Etoposide 1 156.25
5.3058
2.2145
 0.4217 0.4150 2.0284 0.8058
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7246
2.7275
2.5753
 0.0670 0.0593 2.1983 0.3122
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.7102
MCF7 Etoposide 1 312.50
inf
1.0293
 0.5796 0.5970 1.3384 0.8859
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9523
3.2047
1.2216
 0.3269 0.3241 1.0830 0.1956
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9646
MCF7 Etoposide 1 625.00
8.9893
1.4921
 0.4608 0.4521 1.3064 0.8266
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8536
2.0967
1.7154
 0.1530 0.1075 1.2064 0.2794
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8571
MCF7 Etoposide 1 1250.00
3.6183
1.1715
 0.4085 0.4337 1.7922 0.8478
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9544
1.5149
1.3994
 0.0442 0.0564 1.5083 0.2528
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9607
MCF7 Etoposide 1 2500.00
2.7934
0.9707
 0.3808 0.4049 1.5697 0.8029
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9811
1.3557
1.1496
 0.0804 0.1026 1.3922 0.2843
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9843
MCF7 Etoposide 1 5000.00
5.723
1.245
 0.4425 0.3994 1.0513 0.7946
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9871
2.2994
1.4469
 0.2580 0.1958 1.0728 0.2609
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9897
MCF7 Methotrexate 1 156.25
inf
inf
 1.0500 1.0500 0.0000 0.9675
flat fit: x = Einf
0.0
inf
inf
 1.0500 1.0500 0.0000 0.0787
flat fit: x = Einf
-0.0413
MCF7 Methotrexate 1 312.50
inf
inf
 0.8390 0.8390 0.0000 0.8991
flat fit: x = Einf
0.4423
inf
inf
 0.7789 0.7789 0.0000 0.1493
flat fit: x = Einf
0.3991
MCF7 Methotrexate 1 625.00
inf
inf
 0.8825 0.8825 0.0000 0.9293
flat fit: x = Einf
0.3847
inf
inf
 0.6816 0.6816 0.0000 0.2003
flat fit: x = Einf
0.4174
MCF7 Methotrexate 1 1250.00
inf
0.1263
 0.7852 0.7715 5.0000 0.8887
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9095
0.1889
0.1264
 0.4159 0.4329 5.0000 0.2795
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9322
MCF7 Methotrexate 1 2500.00
inf
0.0856
 0.6358 0.6772 5.0000 0.8345
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9466
0.1108
0.0866
 0.2786 0.3539 5.0000 0.3434
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9598
MCF7 Methotrexate 1 5000.00
inf
0.0584
 0.5429 0.5525 3.9662 0.7427
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9881
0.089
0.0597
 0.3808 0.3954 3.9094 0.3493
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9922
MCF7 Lapatinib 10 156.25
11.1916
11.1513
 0.6358 0.0089 5.0000 1.0226
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.8676
9.2068
11.4589
 0.3297 -0.9933 5.0000 -0.0023
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9559
MCF7 Lapatinib 10 312.50
10.5091
10.5083
 0.5612 0.0002 5.0000 1.0062
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.909
8.9871
11.1922
 0.2748 -0.9978 5.0000 0.0160
sigmoidal fit: x = Einf + (1-Einf)/(1+ (x/EC50)^Hill)
0.9589