LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
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| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Withaferin A | 1.11 | uM | LJP6 | 72 | hr | 1476 | 1234 | 3643 | 0.3384 | -0.1313 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP5 | 72 | hr | 1476 | 829 | 3772 | 0.2199 | -0.3472 |
| SK-BR-3 | Withaferin A | 3.33 | uM | LJP6 | 72 | hr | 1476 | 834 | 3643 | 0.2292 | -0.3564 |
| SK-BR-3 | Withaferin A | 10 | uM | LJP5 | 72 | hr | 1476 | 940 | 3772 | 0.2493 | -0.2838 |
| SK-BR-3 | Withaferin A | 10 | uM | LJP6 | 72 | hr | 1476 | 989 | 3643 | 0.2712 | -0.2673 |
| MDA-MB-231 | Seliciclib | 0.04 | uM | LJP5 | 72 | hr | 868 | 3636 | 3410 | 1.0660 | 1.0657 |
| MDA-MB-231 | Seliciclib | 0.12 | uM | LJP5 | 72 | hr | 868 | 3379 | 3410 | 0.9907 | 0.9899 |
| MDA-MB-231 | Seliciclib | 0.37 | uM | LJP5 | 72 | hr | 868 | 3061 | 3410 | 0.8978 | 0.8938 |
| MDA-MB-231 | Seliciclib | 1.11 | uM | LJP5 | 72 | hr | 868 | 2926 | 3410 | 0.8588 | 0.8518 |
| MDA-MB-231 | Seliciclib | 3.33 | uM | LJP5 | 72 | hr | 868 | 2624 | 3410 | 0.7701 | 0.7521 |
| MDA-MB-231 | Seliciclib | 10 | uM | LJP5 | 72 | hr | 868 | 1507 | 3410 | 0.4428 | 0.3232 |
| MDA-MB-231 | AT-7519 | 0.04 | uM | LJP6 | 72 | hr | 868 | 3173 | 3556 | 0.8916 | 0.8887 |
| MDA-MB-231 | AT-7519 | 0.12 | uM | LJP6 | 72 | hr | 868 | 2196 | 3556 | 0.6182 | 0.5787 |
| MDA-MB-231 | AT-7519 | 0.37 | uM | LJP6 | 72 | hr | 868 | 965 | 3556 | 0.2719 | 0.0535 |
| MDA-MB-231 | AT-7519 | 1.11 | uM | LJP6 | 72 | hr | 868 | 722 | 3556 | 0.2028 | -0.0896 |
| MDA-MB-231 | AT-7519 | 3.33 | uM | LJP6 | 72 | hr | 868 | 588 | 3556 | 0.1655 | -0.1747 |
| MDA-MB-231 | AT-7519 | 10 | uM | LJP6 | 72 | hr | 868 | 553 | 3556 | 0.1554 | -0.2010 |
| MDA-MB-231 | AZD7762 | 0.04 | uM | LJP6 | 72 | hr | 868 | 2059 | 3556 | 0.5781 | 0.5263 |
| MDA-MB-231 | AZD7762 | 0.12 | uM | LJP6 | 72 | hr | 868 | 1608 | 3556 | 0.4526 | 0.3540 |
| MDA-MB-231 | AZD7762 | 0.37 | uM | LJP6 | 72 | hr | 868 | 1351 | 3556 | 0.3800 | 0.2425 |
| MDA-MB-231 | AZD7762 | 1.11 | uM | LJP6 | 72 | hr | 868 | 852 | 3556 | 0.2399 | -0.0093 |
| MDA-MB-231 | AZD7762 | 3.33 | uM | LJP6 | 72 | hr | 868 | 683 | 3556 | 0.1921 | -0.1122 |
| MDA-MB-231 | AZD7762 | 10 | uM | LJP6 | 72 | hr | 868 | 633 | 3556 | 0.1784 | -0.1438 |
| MDA-MB-231 | AZD8055 | 0.04 | uM | LJP6 | 72 | hr | 868 | 1801 | 3556 | 0.5085 | 0.4313 |
| MDA-MB-231 | AZD8055 | 0.12 | uM | LJP6 | 72 | hr | 868 | 1409 | 3556 | 0.3979 | 0.2667 |