LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 11 of 15: Mean cell count and mean normalized growth rate inhibition values across biological replicate 1. - Dataset (ID:20248)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Normalized Growth Rate Inhibition Value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| SK-BR-3 | Enzastaurin | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4294 | 3772 | 1.1386 | 1.2015 |
| Hs 578T | Sorafenib | 0.12 | uM | LJP6 | 72 | hr | 929 | 3812 | 3216 | 1.1852 | 1.1991 |
| BT-20 | Enzastaurin | 3.33 | uM | LJP5 | 72 | hr | 1657 | 6589 | 5588 | 1.1796 | 1.1970 |
| SK-BR-3 | XL147 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4284 | 3772 | 1.1358 | 1.1969 |
| Hs 578T | Sorafenib | 0.04 | uM | LJP6 | 72 | hr | 929 | 3783 | 3216 | 1.1761 | 1.1895 |
| MCF7 | PIK-93 | 0.37 | uM | LJP5 | 72 | hr | 1235 | 5022 | 4267 | 1.1763 | 1.1893 |
| SK-BR-3 | Imatinib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4092 | 3643 | 1.1233 | 1.1875 |
| Hs 578T | SB590885 | 0.12 | uM | LJP5 | 72 | hr | 929 | 3796 | 3237 | 1.1726 | 1.1849 |
| SK-BR-3 | SB590885 | 1.11 | uM | LJP5 | 72 | hr | 1476 | 4251 | 3772 | 1.1270 | 1.1846 |
| SK-BR-3 | Linifanib | 1.11 | uM | LJP6 | 72 | hr | 1476 | 4083 | 3643 | 1.1209 | 1.1841 |
| SK-BR-3 | PD173074 | 0.37 | uM | LJP6 | 72 | hr | 1476 | 4062 | 3643 | 1.1173 | 1.1824 |
| Hs 578T | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 929 | 3785 | 3237 | 1.1691 | 1.1812 |
| Hs 578T | PLX-4720 | 1.11 | uM | LJP5 | 72 | hr | 929 | 3783 | 3237 | 1.1683 | 1.1803 |
| Hs 578T | HG-6-64-01 | 0.04 | uM | LJP6 | 72 | hr | 929 | 3750 | 3216 | 1.1660 | 1.1789 |
| SK-BR-3 | NVP-AEW541 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4233 | 3772 | 1.1225 | 1.1784 |
| SK-BR-3 | XL147 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4230 | 3772 | 1.1217 | 1.1770 |
| MCF7 | PD173074 | 1.11 | uM | LJP6 | 72 | hr | 1235 | 4692 | 4056 | 1.1566 | 1.1765 |
| SK-BR-3 | SB590885 | 0.12 | uM | LJP5 | 72 | hr | 1476 | 4225 | 3772 | 1.1202 | 1.1751 |
| SK-BR-3 | SU11274 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4224 | 3772 | 1.1201 | 1.1751 |
| SK-BR-3 | CGP60474 | 0.04 | uM | LJP5 | 72 | hr | 1476 | 4222 | 3772 | 1.1193 | 1.1735 |
| SK-BR-3 | SB590885 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4221 | 3772 | 1.1191 | 1.1731 |
| SK-BR-3 | PLX-4720 | 0.37 | uM | LJP5 | 72 | hr | 1476 | 4215 | 3772 | 1.1174 | 1.1702 |
| SK-BR-3 | Linifanib | 3.33 | uM | LJP6 | 72 | hr | 1476 | 4062 | 3643 | 1.1133 | 1.1693 |
| MCF7 | PIK-93 | 0.12 | uM | LJP5 | 72 | hr | 1235 | 4937 | 4267 | 1.1567 | 1.1690 |
| MCF7 | PIK-93 | 0.04 | uM | LJP5 | 72 | hr | 1235 | 4925 | 4267 | 1.1553 | 1.1686 |