LINCS Pilot Phase Joint Project: Sensitivity measures of six breast cancer cell lines to a library of small molecule kinase inhibitors (single drug treatments). Dataset 5 of 15: Mean cell count and mean growth rate across biological replicate 2. - Dataset (ID:20241)
Download: Excel (XLSX), Comma-separated (CSV)
| Cell | Small Molecule | Small Mol Concentration | Small Mol Conc Unit | LJP Library Plate | Timepoint | Timepoint Unit | Mean Total Cell Count Before Treatment | Mean Total Cell Count After Treatment | Mean Total Control Cell Count | Mean Relative Cell Count | Mean Relative Growth Rate After Treatment |
|---|---|---|---|---|---|---|---|---|---|---|---|
| MCF7 | GW843682X | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1588 | 5667 | 0.2803 | 0.0466 |
| MCF7 | HG-5-113-01 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 990 | 5667 | 0.1747 | -0.0933 |
| MCF7 | HG-5-88-01 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1247 | 5667 | 0.2200 | -0.0332 |
| MCF7 | Imatinib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 4976 | 5667 | 0.8779 | 0.8383 |
| MCF7 | JNK-9L | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1219 | 5667 | 0.2152 | -0.0396 |
| MCF7 | JW-7-24-1 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1059 | 5667 | 0.1870 | -0.0770 |
| MCF7 | Lapatinib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 2624 | 5667 | 0.4631 | 0.2888 |
| MCF7 | LDN-193189 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 536 | 5667 | 0.0947 | -0.1993 |
| MCF7 | Linifanib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1841 | 5667 | 0.3248 | 0.1056 |
| MCF7 | Linsitinib | 10.0 | uM | LJP5 | 72 | hr | 1389 | 2659 | 5667 | 0.4692 | 0.2969 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP5 | 72 | hr | 1389 | 296 | 5667 | 0.0523 | -0.2553 |
| MCF7 | Mitoxantrone | 10.0 | uM | LJP6 | 72 | hr | 1389 | 345 | 5667 | 0.0609 | -0.2439 |
| MCF7 | MK2206 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1453 | 5667 | 0.2565 | 0.0151 |
| MCF7 | Neratinib | 10.0 | uM | LJP5 | 72 | hr | 1389 | 2041 | 5667 | 0.3601 | 0.1524 |
| MCF7 | Nilotinib | 10.0 | uM | LJP5 | 72 | hr | 1389 | 1619 | 5667 | 0.2857 | 0.0539 |
| MCF7 | Nintedanib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 2134 | 5667 | 0.3765 | 0.1741 |
| MCF7 | NU7441 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 3490 | 5667 | 0.6158 | 0.4911 |
| MCF7 | Dactolisib | 10.0 | uM | LJP5 | 72 | hr | 1389 | 1854 | 5667 | 0.3271 | 0.1087 |
| MCF7 | NVP-TAE684 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 966 | 5667 | 0.1706 | -0.0987 |
| MCF7 | Palbociclib | 10.0 | uM | LJP6 | 72 | hr | 1389 | 2357 | 5667 | 0.4159 | 0.2262 |
| MCF7 | PD0325901 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 1384 | 5667 | 0.2443 | -0.0011 |
| MCF7 | PD0325901 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 1461 | 5667 | 0.2578 | 0.0169 |
| MCF7 | PD173074 | 10.0 | uM | LJP6 | 72 | hr | 1389 | 2736 | 5667 | 0.4828 | 0.3150 |
| MCF7 | PD184352 | 10.0 | uM | LJP5 | 72 | hr | 1389 | 2750 | 5667 | 0.4853 | 0.3182 |
| MCF7 | Pelitinib | 10.0 | uM | LJP5 | 72 | hr | 1389 | 782 | 5667 | 0.1381 | -0.1418 |