Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Pevonedistat | MX1 | -4.1759 | 0.9145 | -5.4924 | -5.3995 | -5.8469 | 1.9455 | 0.1538 | 0.1669 | 7.1559 |
| Pevonedistat | T47DKBLUC | -4.1759 | 0.9390 | -6.8359 | -4.1759 | -6.7977 | 4.0000 | 0.5091 | 0.5091 | 6.7562 |
| Pevonedistat | 600MPE | -4.1759 | 0.9575 | -6.4919 | -5.9403 | -6.5451 | 1.5990 | 0.4345 | 0.4346 | 6.7657 |
| Pevonedistat | HCC2185 | -4.1759 | 0.7042 | -4.7199 | -4.1759 | -4.8044 | 3.9970 | 0.7577 | 0.7593 | 8.3530 |
| Pevonedistat | HCC3153 | -4.1759 | 0.9429 | -6.2109 | -6.0351 | -6.4952 | 1.1016 | 0.1752 | 0.1937 | 6.0892 |
| Pevonedistat | LY2 | -4.1759 | 0.8895 | -6.5639 | -6.4386 | -6.7672 | 2.2050 | 0.2349 | 0.2349 | 6.6588 |
| Pevonedistat | ZR75B | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.3236 |
| NSC 663284 | MCF7 | -3.7773 | 0.9778 | -5.3003 | -5.2999 | -5.4890 | 1.8460 | 0.0014 | 0.0030 | 6.1622 |
| NSC 663284 | SK-BR-3 | -3.7773 | 0.9826 | -5.6973 | -5.6963 | -5.8666 | 2.2740 | 0.0020 | 0.0021 | 5.6687 |
| NSC 663284 | MDA-MB-231 | -3.7773 | 0.8289 | -5.0463 | -5.0464 | -5.0852 | 3.9980 | 0.0010 | 0.0010 | 7.8214 |
| NSC 663284 | AU565 | -3.7773 | 0.9878 | -5.6613 | -5.6574 | -5.8312 | 1.8550 | 0.0085 | 0.0088 | 5.8452 |
| NSC 663284 | BT-20 | -3.7773 | 0.9674 | -5.2248 | -5.2249 | -5.5083 | 1.6885 | 0.0000 | 0.0049 | 6.2020 |
| NSC 663284 | BT-474 | -3.7773 | 0.9591 | -5.5033 | -5.5005 | -5.6987 | 2.6030 | 0.0115 | 0.0115 | 5.6622 |
| NSC 663284 | BT-483 | -3.7773 | 0.9777 | -5.2713 | -5.2711 | -6.1132 | 1.1705 | 0.0000 | 0.0181 | 6.2194 |
| NSC 663284 | BT-549 | -3.7773 | 0.9460 | -5.7783 | -5.7783 | -5.8284 | 2.2480 | 0.0000 | 0.0000 | 5.1918 |
| NSC 663284 | CAMA-1 | -3.7773 | 0.9767 | -5.4553 | -5.4544 | -5.6787 | 2.3970 | 0.0081 | 0.0081 | 5.9559 |
| NSC 663284 | HCC1143 | -3.7773 | 0.9704 | -5.7193 | -5.7182 | -5.7802 | 3.9760 | 0.0066 | 0.0066 | 5.6639 |
| NSC 663284 | HCC1395 | -3.7773 | 0.9617 | -5.8053 | -5.8056 | -6.1862 | 1.3185 | 0.0000 | 0.0033 | 5.2136 |
| NSC 663284 | HCC1419 | -3.7773 | 0.9496 | -5.3373 | -5.3377 | -5.7659 | 1.4760 | 0.0000 | 0.0050 | 5.9643 |
| NSC 663284 | HCC1428 | -3.7773 | 0.9890 | -5.3218 | -5.3191 | -5.5278 | 2.9250 | 0.0089 | 0.0091 | 6.2140 |
| NSC 663284 | HCC1569 | -3.7773 | 0.9759 | -5.3183 | -5.3169 | -5.4529 | 3.1100 | 0.0063 | 0.0063 | 6.2815 |
| NSC 663284 | HCC1806 | -3.7773 | 0.9532 | -5.6083 | -5.6067 | -5.6892 | 2.3190 | 0.0040 | 0.0040 | 5.6257 |
| NSC 663284 | HCC1937 | -3.7773 | 0.9562 | -5.8103 | -5.8102 | -6.1033 | 1.4070 | 0.0000 | 0.0014 | 5.2158 |
| NSC 663284 | HCC1954 | -3.7773 | 0.9573 | -5.0843 | -5.0841 | -5.2062 | 2.3510 | 0.0000 | 0.0008 | 6.7370 |
| NSC 663284 | HCC202 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |