Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| Oxamflatin | UACC-893 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Oxamflatin | ZR-75-1 | -4.1759 | 0.8917 | -5.2339 | -5.2338 | -5.8003 | 0.8610 | 0.0000 | 0.1221 | 6.5229 |
| Oxamflatin | 184B5 | -4.1759 | 0.9703 | -5.7669 | -5.7673 | -6.1054 | 0.8821 | 0.0000 | 0.0380 | 6.0728 |
| Oxamflatin | HCC1187 | -4.1759 | 0.9877 | -5.9269 | -5.9264 | -6.2188 | 1.3320 | 0.0008 | 0.0055 | 5.9927 |
| Oxamflatin | MCF 10A | -4.1759 | 0.9791 | -6.0869 | -6.0874 | -6.1679 | 1.5620 | 0.0000 | 0.0010 | 5.9056 |
| Oxamflatin | MCF 10F | -4.1759 | 0.9636 | -5.3359 | -5.3290 | -5.4579 | 2.6640 | 0.0216 | 0.0224 | 7.2158 |
| Oxamflatin | SUM1315MO2 | -4.1759 | 0.9956 | -5.5429 | -5.5385 | -5.6928 | 4.0000 | 0.0209 | 0.0209 | 6.6406 |
| Oxamflatin | SUM149PT | -4.1759 | 0.9795 | -6.1424 | -6.1413 | -6.2702 | 1.4165 | 0.0013 | 0.0031 | 5.5892 |
| Oxamflatin | SUM159PT | -4.1759 | 0.9761 | -6.5109 | -6.5109 | -6.5601 | 0.8270 | 0.0000 | 0.0116 | 5.0234 |
| Oxamflatin | SUM185PE | -4.1759 | 0.8426 | -5.7529 | -5.7530 | -6.4836 | 0.7646 | 0.0000 | 0.0586 | 6.2274 |
| Oxamflatin | SUM225CWN | -4.1759 | 0.9009 | -5.6769 | -5.6766 | -6.1498 | 0.9256 | 0.0000 | 0.0392 | 6.0229 |
| Oxamflatin | SUM229PE | -4.1759 | 0.9831 | -5.6699 | -5.6469 | -5.7802 | 1.5940 | 0.0407 | 0.0447 | 6.4204 |
| Oxamflatin | SUM52PE | -4.1759 | 0.9538 | -5.9724 | -5.9715 | -6.2501 | 1.1790 | 0.0018 | 0.0123 | 6.0320 |
| Oxamflatin | 184A1 | -4.1759 | 0.9668 | -5.5309 | -5.5309 | -5.8431 | 1.3640 | 0.0000 | 0.0140 | 6.5726 |
| Oxamflatin | MCF12A | -4.1759 | 0.9898 | -5.5399 | -5.5398 | -5.6994 | 2.0430 | 0.0000 | 0.0016 | 6.5077 |
| Oxamflatin | MX1 | -4.1759 | 0.9779 | -5.9559 | -5.9498 | -6.3119 | 1.5240 | 0.0142 | 0.0143 | 6.2829 |
| Oxamflatin | T47DKBLUC | -4.1759 | 0.9806 | -5.6379 | -5.6375 | -5.9379 | 1.2920 | 0.0000 | 0.0128 | 6.1175 |
| Oxamflatin | 600MPE | -4.1759 | 0.9701 | -5.0500 | -5.0501 | -5.5698 | 1.1650 | 0.0000 | 0.0875 | 7.0899 |
| Oxamflatin | HCC2185 | -4.1759 | 0.9665 | -5.8699 | -5.8699 | -6.4501 | 1.2275 | 0.0000 | 0.0086 | 5.9490 |
| Oxamflatin | HCC3153 | -4.1759 | 0.9586 | -5.5159 | -5.5159 | -5.8101 | 1.3400 | 0.0000 | 0.0158 | 6.5957 |
| Oxamflatin | LY2 | -4.1759 | 0.8976 | -5.5809 | -5.5697 | -5.7705 | 3.0930 | 0.0397 | 0.0398 | 6.9704 |
| Oxamflatin | ZR75B | -4.1759 | 0.9727 | -6.1089 | -6.1092 | -6.4794 | 0.8264 | 0.0000 | 0.0246 | 5.4816 |
| (Z)-4-Hydroxytamoxifen | MCF7 | -3.7773 | 0.7486 | -4.6808 | -3.9578 | -4.1395 | 0.4719 | 0.2859 | 0.5291 | 7.6945 |
| (Z)-4-Hydroxytamoxifen | SK-BR-3 | -3.7773 | 0.9458 | -4.1586 | -4.1585 | -4.3487 | 1.5390 | 0.0000 | 0.2057 | 7.7884 |
| (Z)-4-Hydroxytamoxifen | MDA-MB-231 | -3.7773 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.6721 |