Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| GSK1838705A | SUM159PT | -4.1759 | 0.8863 | -5.5889 | -5.5468 | -5.5706 | 3.9810 | 0.1609 | 0.1609 | 7.3297 |
| GSK1838705A | SUM185PE | -4.1759 | 0.9364 | -5.3819 | -5.3821 | -5.6140 | 2.6910 | 0.0000 | 0.0006 | 6.4731 |
| GSK1838705A | SUM225CWN | -4.1759 | 0.9261 | -5.0409 | -5.0272 | -5.1909 | 3.3895 | 0.0480 | 0.0507 | 7.8075 |
| GSK1838705A | SUM229PE | -4.1759 | 0.9674 | -5.9299 | -5.8999 | -6.2471 | 1.2130 | 0.0021 | 0.0171 | 5.9400 |
| GSK1838705A | SUM52PE | -4.1759 | 0.9247 | -5.5534 | -5.5537 | -5.8807 | 1.0247 | 0.0000 | 0.0393 | 6.0676 |
| GSK1838705A | 184A1 | -4.1759 | 0.9532 | -6.4634 | -6.1300 | -6.4424 | 1.9500 | 0.3760 | 0.3760 | 6.8062 |
| GSK1838705A | MCF12A | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK1838705A | MX1 | -4.1759 | 0.8230 | -5.3319 | -5.2859 | -5.4355 | 3.9940 | 0.1715 | 0.1715 | 7.3210 |
| GSK1838705A | T47DKBLUC | -4.1759 | 0.9379 | -4.7200 | -4.7200 | -4.9068 | 2.5810 | 0.0000 | 0.0379 | 7.5669 |
| GSK1838705A | 600MPE | -4.1759 | 0.9660 | -5.9359 | -5.9341 | -6.6262 | 0.7191 | 0.0016 | 0.0595 | 5.8907 |
| GSK1838705A | HCC2185 | -4.1759 | 0.9608 | -5.2439 | -5.1059 | -5.6371 | 1.9110 | 0.2321 | 0.2321 | 7.3995 |
| GSK1838705A | HCC3153 | -4.1759 | 0.8058 | -5.0540 | -4.6945 | -5.4372 | 0.9019 | 0.1531 | 0.3092 | 7.5270 |
| GSK1838705A | LY2 | -4.1759 | 0.8713 | -6.3749 | -6.1871 | -6.3548 | 3.9990 | 0.4116 | 0.4116 | 7.1347 |
| GSK1838705A | ZR75B | -4.1759 | 0.9847 | -4.7853 | -4.7853 | -4.9741 | 1.5510 | 0.0000 | 0.1019 | 7.5499 |
| GSK923295 | MCF7 | -4.4776 | 0.8675 | -5.8090 | -4.4776 | -5.7399 | 0.5729 | 0.2454 | 0.5364 | 7.5521 |
| GSK923295 | SK-BR-3 | -4.4776 | 0.9690 | -7.3406 | -7.2206 | -7.4144 | 3.3410 | 0.2261 | 0.2261 | 5.7292 |
| GSK923295 | MDA-MB-231 | -4.4776 | 0.9476 | -7.4406 | -7.2762 | -7.3785 | 1.9990 | 0.3026 | 0.3026 | 5.8534 |
| GSK923295 | AU565 | -4.4776 | 0.9743 | -7.6196 | -7.5660 | -7.7122 | 2.9380 | 0.1295 | 0.1295 | 4.6744 |
| GSK923295 | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| GSK923295 | BT-474 | -4.4776 | 0.8546 | -5.0067 | -4.8562 | -5.6180 | 1.1830 | 0.0000 | 0.2108 | 7.5661 |
| GSK923295 | BT-483 | -4.4776 | 0.7399 | -6.8686 | -4.4776 | -7.1077 | 0.3992 | 0.6796 | 0.7119 | 7.8583 |
| GSK923295 | BT-549 | -4.4776 | 0.9726 | -7.3356 | -7.2273 | -7.2973 | 3.9990 | 0.3149 | 0.3149 | 6.0724 |
| GSK923295 | CAMA-1 | -4.4776 | 0.9171 | -7.3906 | -4.4776 | -7.4011 | 3.9990 | 0.5231 | 0.5231 | 6.7121 |
| GSK923295 | HCC1143 | -4.4776 | 0.8172 | -7.1321 | -5.3503 | -7.1299 | 1.0993 | 0.5082 | 0.5099 | 7.0065 |
| GSK923295 | HCC1395 | -4.4776 | 0.9507 | -7.3346 | -7.1900 | -7.4848 | 2.9095 | 0.2759 | 0.2759 | 5.6704 |