Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| LBH589 | MDA-MB-175-VII | -4.4776 | 0.9630 | -6.0841 | -6.0079 | -6.4724 | 1.6865 | 0.1224 | 0.1242 | 6.3197 |
| LBH589 | MDA-MB-361 | -4.4776 | 0.9827 | -7.1281 | -7.1231 | -7.4381 | 2.7945 | 0.0145 | 0.0146 | 4.9033 |
| LBH589 | MDA-MB-436 | -4.4776 | 0.9516 | -6.3536 | -6.0862 | -6.5173 | 1.3020 | 0.2760 | 0.2786 | 6.7658 |
| LBH589 | MDA-MB-453 | -4.4776 | 0.9875 | -7.2396 | -7.2363 | -7.3376 | 3.9980 | 0.0146 | 0.0146 | 4.7005 |
| LBH589 | MDA-MB-468 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| LBH589 | T47D | -4.4776 | 0.9808 | -6.7846 | -6.7806 | -6.8891 | 2.5960 | 0.0133 | 0.0133 | 5.1480 |
| LBH589 | UACC-812 | -4.4776 | 0.9511 | -6.5696 | -6.5409 | -6.8655 | 1.5690 | 0.0509 | 0.0516 | 5.4854 |
| LBH589 | UACC-893 | -4.4776 | 0.9761 | -7.0046 | -6.9947 | -7.3599 | 2.3230 | 0.0257 | 0.0257 | 5.1391 |
| LBH589 | ZR-75-1 | -4.4776 | 0.8910 | -6.5121 | -6.1297 | -6.8702 | 1.1378 | 0.1956 | 0.2232 | 6.1081 |
| LBH589 | 184B5 | -4.4776 | 0.9694 | -6.6326 | -6.4825 | -7.0115 | 0.6120 | 0.0953 | 0.1368 | 5.8331 |
| LBH589 | HCC1187 | -4.4776 | 0.9872 | -6.6896 | -6.6822 | -6.7678 | 4.0000 | 0.0320 | 0.0320 | 5.6436 |
| LBH589 | MCF 10A | -4.4776 | 0.9680 | -6.8196 | -6.8174 | -6.8899 | 1.5830 | 0.0037 | 0.0039 | 5.1318 |
| LBH589 | MCF 10F | -4.4776 | 0.9672 | -5.9386 | -5.9106 | -6.0075 | 3.2480 | 0.0943 | 0.0943 | 7.0861 |
| LBH589 | SUM1315MO2 | -4.4776 | 0.9789 | -6.2631 | -6.2382 | -6.6278 | 1.4445 | 0.0359 | 0.0419 | 6.1761 |
| LBH589 | SUM149PT | -4.4776 | 0.9691 | -6.5836 | -6.5824 | -6.6713 | 2.1145 | 0.0021 | 0.0022 | 5.3998 |
| LBH589 | SUM159PT | -4.4776 | 0.9636 | -6.8996 | -6.8992 | -6.9383 | 1.3160 | 0.0000 | 0.0006 | 4.9535 |
| LBH589 | SUM185PE | -4.4776 | 0.9596 | -6.7176 | -6.6847 | -7.1017 | 1.1760 | 0.0423 | 0.0446 | 5.4740 |
| LBH589 | SUM225CWN | -4.4776 | 0.9429 | -6.6066 | -6.5968 | -6.9399 | 1.4380 | 0.0161 | 0.0170 | 5.7102 |
| LBH589 | SUM229PE | -4.4776 | 0.9446 | -6.4706 | -6.4482 | -6.5547 | 2.0380 | 0.0501 | 0.0502 | 5.9048 |
| LBH589 | SUM52PE | -4.4776 | 0.9673 | -6.7156 | -6.7079 | -6.8578 | 2.8885 | 0.0217 | 0.0218 | 5.4062 |
| LBH589 | 184A1 | -4.4776 | 0.9699 | -6.2706 | -6.2229 | -6.5818 | 0.9837 | 0.0517 | 0.0677 | 6.2712 |
| LBH589 | MCF12A | -4.4776 | 0.9927 | -6.2826 | -6.2682 | -6.4164 | 2.5235 | 0.0237 | 0.0267 | 5.9745 |
| LBH589 | MX1 | -4.4776 | 0.9881 | -6.8306 | -6.8226 | -7.1722 | 1.6940 | 0.0147 | 0.0148 | 5.2337 |
| LBH589 | T47DKBLUC | -4.4776 | 0.9929 | -6.6796 | -6.6784 | -6.8953 | 1.7730 | 0.0028 | 0.0030 | 5.3574 |
| LBH589 | 600MPE | -4.4776 | 0.9730 | -6.3906 | -6.3590 | -6.7110 | 1.4490 | 0.0500 | 0.0516 | 5.8321 |