Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| LBH589 | HCC2185 | -4.4776 | 0.9700 | -6.8851 | -6.8798 | -7.1914 | 2.3935 | 0.0146 | 0.0146 | 5.1373 |
| LBH589 | HCC3153 | -4.4776 | 0.9714 | -6.4376 | -6.3722 | -6.5628 | 1.8230 | 0.1191 | 0.1193 | 6.0384 |
| LBH589 | LY2 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| LBH589 | ZR75B | -4.4776 | 0.9654 | -6.9396 | -6.9223 | -7.1296 | 1.3350 | 0.0258 | 0.0263 | 4.9583 |
| Pevonedistat | MCF7 | -4.1759 | 0.9836 | -6.4399 | -6.1838 | -7.1668 | 0.7465 | 0.1781 | 0.1945 | 5.8664 |
| Pevonedistat | SK-BR-3 | -4.1759 | 0.8802 | -6.9829 | -5.7203 | -6.8970 | 0.8763 | 0.4609 | 0.4628 | 6.4888 |
| Pevonedistat | MDA-MB-231 | -4.1759 | 0.9675 | -6.9149 | -6.9070 | -7.0527 | 1.1010 | 0.0093 | 0.0102 | 4.8132 |
| Pevonedistat | AU565 | -4.1759 | 0.9700 | -6.7649 | -6.6571 | -6.8026 | 2.3630 | 0.2215 | 0.2215 | 5.6749 |
| Pevonedistat | BT-20 | -4.1759 | 0.9446 | -5.3814 | -5.3037 | -5.6957 | 1.6475 | 0.1262 | 0.1351 | 6.8520 |
| Pevonedistat | BT-474 | -4.1759 | 0.8119 | -6.0089 | -4.1759 | -6.3137 | 0.7222 | 0.4512 | 0.5128 | 7.0802 |
| Pevonedistat | BT-483 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 8.1815 |
| Pevonedistat | BT-549 | -4.1759 | 0.9841 | -6.5479 | -6.5022 | -6.5905 | 1.6490 | 0.0806 | 0.0807 | 5.3857 |
| Pevonedistat | CAMA-1 | -4.1759 | 0.9062 | -7.1969 | -6.7206 | -7.3820 | 1.5490 | 0.4241 | 0.4260 | 6.0696 |
| Pevonedistat | HCC1143 | -4.1759 | 0.9046 | -6.2759 | -6.0657 | -6.6626 | 0.4636 | 0.1006 | 0.1870 | 5.7173 |
| Pevonedistat | HCC1395 | -4.1759 | 0.8743 | -4.1666 | -4.5519 | -6.0401 | 0.3010 | 0.0000 | 0.5016 | 7.2534 |
| Pevonedistat | HCC1419 | -4.1759 | 0.9609 | -6.2799 | -5.9280 | -6.6347 | 1.6280 | 0.3662 | 0.3664 | 6.5772 |
| Pevonedistat | HCC1428 | -4.1759 | 0.8709 | -7.1224 | -4.1759 | -6.9644 | 1.4573 | 0.6180 | 0.6183 | 7.0586 |
| Pevonedistat | HCC1569 | -4.1759 | 0.8469 | -5.8629 | -4.1759 | -5.6430 | 0.5406 | 0.5928 | 0.6372 | 7.9236 |
| Pevonedistat | HCC1806 | -4.1759 | 0.9848 | -7.5899 | -7.5013 | -7.7031 | 1.1370 | 0.1033 | 0.1034 | 4.1940 |
| Pevonedistat | HCC1937 | -4.1759 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | 7.2649 |
| Pevonedistat | HCC1954 | -4.1759 | 0.9458 | -5.3749 | -5.0988 | -5.3948 | 1.3180 | 0.2834 | 0.3018 | 7.2647 |
| Pevonedistat | HCC202 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| Pevonedistat | HCC38 | -4.1759 | 0.9650 | -7.1789 | -7.1367 | -7.3541 | 1.2340 | 0.0527 | 0.0532 | 4.2528 |
| Pevonedistat | HCC70 | -4.1759 | 0.9930 | -6.6609 | -6.6406 | -6.8199 | 2.1660 | 0.0477 | 0.0477 | 6.3764 |
| Pevonedistat | Hs 578T | -4.1759 | 0.9170 | -6.5379 | -6.4763 | -6.7101 | 0.7116 | 0.0478 | 0.0672 | 5.0846 |