Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | HCC1143 | -4.0000 | 0.9195 | -6.9035 | -6.7919 | -6.9496 | 3.9990 | 0.3182 | 0.3182 | 5.9113 |
| 17-AAG | HCC1395 | -4.0000 | 0.8972 | -5.9790 | -5.7146 | -6.7611 | 0.5356 | 0.1172 | 0.1989 | 6.3873 |
| 17-AAG | HCC1419 | -4.0000 | 0.9222 | -6.7240 | -6.4874 | -7.5167 | 0.9458 | 0.1718 | 0.1854 | 5.6387 |
| 17-AAG | HCC1428 | -4.0000 | 0.8383 | -6.1110 | -6.1114 | -7.7390 | 0.3469 | 0.0000 | 0.1562 | 5.4574 |
| 17-AAG | HCC1569 | -4.0000 | 0.9600 | -6.7970 | -6.6593 | -6.8748 | 2.5205 | 0.2149 | 0.2154 | 5.4975 |
| 17-AAG | HCC1806 | -4.0000 | 0.9833 | -7.0180 | -6.9621 | -7.0904 | 2.5740 | 0.1416 | 0.1416 | 4.9223 |
| 17-AAG | HCC1937 | -4.0000 | 0.9736 | -6.9450 | -6.8969 | -6.9901 | 3.9990 | 0.1822 | 0.1822 | 5.2613 |
| 17-AAG | HCC1954 | -4.0000 | 0.9123 | -7.4570 | -7.2736 | -7.5312 | 2.1480 | 0.1899 | 0.1899 | 4.6514 |
| 17-AAG | HCC202 | -4.0000 | 0.8793 | -6.3950 | -6.1120 | -7.8220 | 0.4610 | 0.1621 | 0.2232 | 5.7129 |
| 17-AAG | HCC38 | -4.0000 | 0.9507 | -7.0200 | -6.8296 | -7.2836 | 1.4475 | 0.2327 | 0.2334 | 5.4493 |
| 17-AAG | HCC70 | -4.0000 | 0.9574 | -6.3990 | -6.2152 | -6.6518 | 1.4880 | 0.1835 | 0.1884 | 6.0999 |
| 17-AAG | Hs 578T | -4.0000 | 0.9740 | -6.9270 | -6.8681 | -7.0130 | 2.5315 | 0.1496 | 0.1496 | 5.0655 |
| 17-AAG | MB 157 | -4.0000 | 0.9577 | -6.4890 | -6.2742 | -6.8824 | 1.6810 | 0.2822 | 0.2823 | 6.1554 |
| 17-AAG | MDA-MB-134-VI | -4.0000 | 0.9871 | -7.1850 | -7.1306 | -7.3874 | 2.5250 | 0.1285 | 0.1285 | 4.6601 |
| 17-AAG | MDA-MB-157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | MDA-MB-175-VII | -4.0000 | 0.9160 | -7.2050 | -6.9902 | -7.5040 | 1.7460 | 0.2454 | 0.2454 | 5.3651 |
| 17-AAG | MDA-MB-361 | -4.0000 | 0.9853 | -7.1865 | -7.1428 | -7.2781 | 3.9990 | 0.1527 | 0.1527 | 4.8491 |
| 17-AAG | MDA-MB-436 | -4.0000 | 0.7863 | -5.1445 | -5.1444 | -6.2076 | 0.4534 | 0.0000 | 0.2328 | 6.7347 |
| 17-AAG | MDA-MB-453 | -4.0000 | 0.9623 | -7.3180 | -7.2574 | -7.4074 | 3.1290 | 0.1702 | 0.1702 | 4.6811 |
| 17-AAG | MDA-MB-468 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | T47D | -4.0000 | 0.9673 | -5.9600 | -5.5842 | -6.0116 | 1.3960 | 0.3505 | 0.3517 | 6.8051 |
| 17-AAG | UACC-812 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | UACC-893 | -4.0000 | 0.8927 | -7.1970 | -7.1266 | -7.3685 | 2.6970 | 0.1775 | 0.1775 | 4.8815 |
| 17-AAG | ZR-75-1 | -4.0000 | 0.9417 | -6.8275 | -6.6116 | -6.8577 | 3.3130 | 0.3959 | 0.3959 | 6.4398 |
| 17-AAG | 184B5 | -4.0000 | 0.9840 | -7.5290 | -7.4996 | -7.6292 | 3.9990 | 0.1172 | 0.1172 | 4.1652 |