Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
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| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | HCC1187 | -4.0000 | 0.8605 | -5.4455 | -5.2561 | -5.6429 | 2.1765 | 0.2686 | 0.2708 | 6.9055 |
| 17-AAG | MCF 10A | -4.0000 | 0.9898 | -7.3650 | -7.3423 | -7.4309 | 2.4565 | 0.0490 | 0.0490 | 3.9543 |
| 17-AAG | MCF 10F | -4.0000 | 0.9743 | -7.3525 | -7.3037 | -7.4975 | 2.2345 | 0.1044 | 0.1044 | 4.2062 |
| 17-AAG | SUM1315MO2 | -4.0000 | 0.8799 | -6.6145 | -6.5024 | -7.8064 | 1.2761 | 0.1652 | 0.2197 | 5.5249 |
| 17-AAG | SUM149PT | -4.0000 | 0.9897 | -7.1095 | -7.1017 | -7.1526 | 3.5090 | 0.0314 | 0.0314 | 4.1167 |
| 17-AAG | SUM159PT | -4.0000 | 0.9526 | -7.4530 | -7.4356 | -7.4727 | 2.8720 | 0.0503 | 0.0503 | 3.8932 |
| 17-AAG | SUM185PE | -4.0000 | 0.8775 | -7.3695 | -7.2978 | -7.5310 | 3.1600 | 0.1923 | 0.1923 | 4.8675 |
| 17-AAG | SUM225CWN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | SUM229PE | -4.0000 | 0.9060 | -7.4045 | -7.2089 | -7.6089 | 1.1620 | 0.2040 | 0.2040 | 4.6731 |
| 17-AAG | SUM52PE | -4.0000 | 0.8939 | -7.2410 | -6.9159 | -7.7059 | 0.8461 | 0.2178 | 0.2196 | 5.0957 |
| 17-AAG | 184A1 | -4.0000 | 0.8258 | -7.7910 | -7.5836 | -8.0006 | 2.4610 | 0.3454 | 0.3454 | 5.1026 |
| 17-AAG | MCF12A | -4.0000 | 0.9858 | -7.3260 | -7.3244 | -7.4672 | 2.5180 | 0.0545 | 0.0545 | 4.3677 |
| 17-AAG | MX1 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | T47DKBLUC | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | 600MPE | -4.0000 | 0.8393 | -5.9890 | -5.7998 | -7.3145 | 0.8335 | 0.1732 | 0.3543 | 6.1967 |
| 17-AAG | HCC2185 | -4.0000 | 0.9649 | -6.6605 | -6.4227 | -7.0748 | 1.6940 | 0.2975 | 0.2980 | 5.9764 |
| 17-AAG | HCC3153 | -4.0000 | 0.9756 | -6.7780 | -6.6153 | -6.8203 | 1.8430 | 0.2488 | 0.2488 | 5.6303 |
| 17-AAG | LY2 | -4.0000 | 0.9695 | -7.0545 | -6.9265 | -7.1532 | 1.9675 | 0.2149 | 0.2149 | 5.2425 |
| 17-AAG | ZR75B | -4.0000 | 0.9073 | -7.1760 | -6.5912 | -7.3418 | 0.8582 | 0.3382 | 0.3399 | 5.7616 |
| 5-DFUR | MCF7 | -2.3010 | 0.8187 | -3.6250 | -2.3010 | -3.8407 | 1.0180 | 0.5231 | 0.5436 | 7.6867 |
| 5-DFUR | SK-BR-3 | -2.3010 | 0.8096 | -2.5574 | -2.5574 | NaN | 0.2672 | 0.0000 | 0.4606 | 6.9216 |
| 5-DFUR | MDA-MB-231 | -2.3010 | 0.8760 | -3.4730 | -3.3613 | -3.4799 | 1.2300 | 0.1355 | 0.1657 | 7.6494 |
| 5-DFUR | AU565 | -2.3010 | 0.8667 | -5.3030 | -4.3049 | -5.2191 | 0.5622 | 0.3626 | 0.3754 | 6.0160 |
| 5-DFUR | BT-20 | -2.3010 | 0.8072 | -2.8957 | -2.4068 | -3.5554 | 0.5198 | 0.2009 | 0.4854 | 7.5241 |
| 5-DFUR | BT-474 | -2.3010 | 0.8103 | -2.0940 | -2.3010 | -3.3351 | 0.3593 | 0.0000 | 0.5427 | 8.0229 |