Metrics other than potency reveal systematic variation in responses to cancer drugs - Dataset (ID:20120)
Download: Excel (XLSX), Comma-separated (CSV)
| Small Molecule | Cell Line | log10[max. dose (M)] | R^2 (goodness of fit) | log10[EC50 (M)] | log10[IC50 (M)] | log10[GI50 (M)] | HillSlope | E_inf | E_max | AUC |
|---|---|---|---|---|---|---|---|---|---|---|
| 17-AAG | HCC1806 | -4.0000 | 0.9833 | -7.0180 | -6.9621 | -7.0904 | 2.5740 | 0.1416 | 0.1416 | 4.9223 |
| 17-AAG | MDA-MB-134-VI | -4.0000 | 0.9871 | -7.1850 | -7.1306 | -7.3874 | 2.5250 | 0.1285 | 0.1285 | 4.6601 |
| 17-AAG | BT-483 | -4.0000 | 0.8911 | -5.0552 | -5.0552 | -6.6573 | 0.5425 | 0.0000 | 0.2126 | 6.8792 |
| 17-AAG | HCC1569 | -4.0000 | 0.9600 | -6.7970 | -6.6593 | -6.8748 | 2.5205 | 0.2149 | 0.2154 | 5.4975 |
| 17-AAG | HCC38 | -4.0000 | 0.9507 | -7.0200 | -6.8296 | -7.2836 | 1.4475 | 0.2327 | 0.2334 | 5.4493 |
| 17-AAG | MB 157 | -4.0000 | 0.9577 | -6.4890 | -6.2742 | -6.8824 | 1.6810 | 0.2822 | 0.2823 | 6.1554 |
| 17-AAG | MDA-MB-231 | -4.0000 | 0.9725 | -5.8330 | -5.7006 | -5.8232 | 1.9490 | 0.1923 | 0.1925 | 6.3898 |
| 17-AAG | BT-474 | -4.0000 | 0.9618 | -7.4900 | -7.3357 | -7.8068 | 1.8840 | 0.2443 | 0.2443 | 5.7024 |
| 17-AAG | HCC1143 | -4.0000 | 0.9195 | -6.9035 | -6.7919 | -6.9496 | 3.9990 | 0.3182 | 0.3182 | 5.9113 |
| 17-AAG | HCC1428 | -4.0000 | 0.8383 | -6.1110 | -6.1114 | -7.7390 | 0.3469 | 0.0000 | 0.1562 | 5.4574 |
| 17-AAG | HCC1954 | -4.0000 | 0.9123 | -7.4570 | -7.2736 | -7.5312 | 2.1480 | 0.1899 | 0.1899 | 4.6514 |
| 17-AAG | HCC202 | -4.0000 | 0.8793 | -6.3950 | -6.1120 | -7.8220 | 0.4610 | 0.1621 | 0.2232 | 5.7129 |
| 17-AAG | HCC70 | -4.0000 | 0.9574 | -6.3990 | -6.2152 | -6.6518 | 1.4880 | 0.1835 | 0.1884 | 6.0999 |
| 17-AAG | Hs 578T | -4.0000 | 0.9740 | -6.9270 | -6.8681 | -7.0130 | 2.5315 | 0.1496 | 0.1496 | 5.0655 |
| 17-AAG | MCF7 | -4.0000 | 0.8873 | -6.0400 | -5.5267 | -6.2554 | 0.6306 | 0.2628 | 0.2990 | 6.5267 |
| 17-AAG | SK-BR-3 | -4.0000 | 0.8661 | -7.1800 | -6.4291 | -7.4935 | 0.5343 | 0.2889 | 0.2896 | 5.6780 |
| 17-AAG | AU565 | -4.0000 | 0.8220 | -6.4130 | -6.2516 | -7.0894 | 0.6432 | 0.1231 | 0.2127 | 5.6376 |
| 17-AAG | BT-20 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |
| 17-AAG | BT-549 | -4.0000 | 0.9841 | -7.5275 | -7.5014 | -7.5490 | 3.9985 | 0.0952 | 0.0952 | 4.0970 |
| 17-AAG | CAMA-1 | -4.0000 | 0.9115 | -6.1150 | -5.5666 | -6.6202 | 0.5996 | 0.2504 | 0.2945 | 6.4789 |
| 17-AAG | HCC1395 | -4.0000 | 0.8972 | -5.9790 | -5.7146 | -6.7611 | 0.5356 | 0.1172 | 0.1989 | 6.3873 |
| 17-AAG | HCC1419 | -4.0000 | 0.9222 | -6.7240 | -6.4874 | -7.5167 | 0.9458 | 0.1718 | 0.1854 | 5.6387 |
| 17-AAG | HCC1937 | -4.0000 | 0.9736 | -6.9450 | -6.8969 | -6.9901 | 3.9990 | 0.1822 | 0.1822 | 5.2613 |
| 17-AAG | MDA-MB-175-VII | -4.0000 | 0.9160 | -7.2050 | -6.9902 | -7.5040 | 1.7460 | 0.2454 | 0.2454 | 5.3651 |
| 17-AAG | MDA-MB-157 | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN | NaN |