LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20361)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_9
 Palbociclib 72 1.5113 0.2927 0.2181 0.72834 0.2462 0.9291 0.9902
1.11022302463e-16
MCF10A-GM_7
 Neratinib 72 0.6343 0.1902 0.1983 0.47136 0.1837 1.5425 0.9280
2.69895217286e-13
MCF10A-GM_4
 Neratinib 72 0.3333 0.1249 0.2789 0.25439 0.1756 1.6016 0.8850
4.64310812021e-11
MCF10A-GM_8
 Neratinib 72 0.4944 0.1601 0.2140 0.38258 0.1735 1.6620 0.9455
1.25455201783e-14
MCF10A-GM_8
 Palbociclib 72 1.3076 0.2218 0.2364 0.78812 0.1724 0.8353 0.9515
3.06659142524e-11
MCF10A-GM_5
 Palbociclib 72 0.8421 0.1400 0.2682 0.57902 0.1419 0.8908 0.9852
2.22044604925e-15
MCF10A-GM_5
 Trametinib 72 0.0037 0.1008 0.6277 0.00294 0.1274 1.3150 0.9855
1.11022302463e-16
MCF10A-GM_2
 Trametinib 72 0.0031 0.0932 0.6454 0.00247 0.1261 1.2703 0.9864
1.11022302463e-16
MCF10A-GM_3
 Trametinib 72 0.0032 0.0891 0.6444 0.00254 0.1236 1.1674 0.9882
1.11022302463e-16
MCF10A-GM_9
 Neratinib 72 0.5877 0.1245 0.2085 0.48257 0.1227 1.4294 0.9393
4.10782519111e-14
MCF10A-GM_6
 Trametinib 72 0.0038 0.1052 0.6376 0.00301 0.1167 1.2006 0.9837
1.11022302463e-16
MCF10A-GM_9
 Trametinib 72 0.0038 0.0688 0.6336 0.00308 0.1142 1.3043 0.9848
1.11022302463e-16
MCF10A-GM_1
 Trametinib 72 0.0037 0.0635 0.6324 0.00299 0.1133 1.2768 0.9809
1.11022302463e-16
MCF10A-GM_8
 Trametinib 72 0.0040 0.1027 0.6263 0.00331 0.1110 1.2895 0.9906
1.11022302463e-16
MCF10A-GM_7
 Alpelisib 72 11.5543 0.4925 0.1271 7.97966 0.1098 0.6701 0.9498
5.10702591328e-15
MCF10A-GM_4
 Trametinib 72 0.0035 0.0966 0.6434 0.00287 0.1094 1.2248 0.9799
1.11022302463e-16
MCF10A-GM_6
 Neratinib 72 0.3653 0.1217 0.2764 0.31106 0.1080 1.5128 0.9320
1.43329792479e-13
MCF10A-GM_7
 Trametinib 72 0.0039 0.0719 0.6340 0.00325 0.1062 1.3464 0.9839
1.11022302463e-16
MCF10A-GM_7
 Palbociclib 72 1.2911 0.1975 0.2446 0.98102 0.0926 0.7453 0.9668
1.48003831413e-12
MCF10A-GM_5
 Neratinib 72 0.3531 0.1178 0.2790 0.30699 0.0908 1.4312 0.9264
3.44724249146e-13
MCF10A-GM_2
 Neratinib 72 0.2054 0.0672 0.3563 0.18651 0.0602 1.3299 0.9097
3.26805249529e-12
MCF10A-GM_3
 Palbociclib 72 0.6883 0.0974 0.3032 0.58742 0.0550 0.7356 0.9773
6.93889390391e-14
MCF10A-GM_1
 Neratinib 72 0.1969 0.0642 0.3725 0.18049 0.0506 1.2255 0.8983
1.20580212482e-11
MCF10A-GM_1
 Palbociclib 72 0.3755 0.0386 0.3583 0.32427 0.0472 0.6762 0.9684
9.82769421398e-13
MCF10A-GM_3
 Neratinib 72 0.2022 0.0710 0.3721 0.18743 0.0439 1.2090 0.8942
1.85039761291e-11
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