LINCS MCF 10A Common Project: Fixed-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Repeat performed by Scientist A in 2019 to assess reproducibility. Dataset 2 of 2: Calculated dose response metrics. - Dataset (ID:20361)

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Cell Small Molecule Timepoint GR50 GRmax GR_AOC GEC50 GRinf h_GR r2_GR pval_GR
MCF10A-GM_4
 Neratinib 72 0.3333 0.1249 0.2789 0.25439 0.1756 1.6016 0.8850
4.64310812021e-11
MCF10A-GM_3
 Neratinib 72 0.2022 0.0710 0.3721 0.18743 0.0439 1.2090 0.8942
1.85039761291e-11
MCF10A-GM_1
 Neratinib 72 0.1969 0.0642 0.3725 0.18049 0.0506 1.2255 0.8983
1.20580212482e-11
MCF10A-GM_2
 Neratinib 72 0.2054 0.0672 0.3563 0.18651 0.0602 1.3299 0.9097
3.26805249529e-12
MCF10A-GM_5
 Neratinib 72 0.3531 0.1178 0.2790 0.30699 0.0908 1.4312 0.9264
3.44724249146e-13
MCF10A-GM_7
 Neratinib 72 0.6343 0.1902 0.1983 0.47136 0.1837 1.5425 0.9280
2.69895217286e-13
MCF10A-GM_6
 Neratinib 72 0.3653 0.1217 0.2764 0.31106 0.1080 1.5128 0.9320
1.43329792479e-13
MCF10A-GM_4
 Alpelisib 72 9.9368 0.4353 0.1434 78.91713 -1.0000 0.5302 0.9350
8.71525074331e-14
MCF10A-GM_9
 Neratinib 72 0.5877 0.1245 0.2085 0.48257 0.1227 1.4294 0.9393
4.10782519111e-14
MCF10A-GM_8
 Neratinib 72 0.4944 0.1601 0.2140 0.38258 0.1735 1.6620 0.9455
1.25455201783e-14
MCF10A-GM_6
 Alpelisib 72 9.3375 0.4071 0.1347 69.94454 -1.0000 0.5456 0.9466
9.99200722163e-15
MCF10A-GM_7
 Alpelisib 72 11.5543 0.4925 0.1271 7.97966 0.1098 0.6701 0.9498
5.10702591328e-15
MCF10A-GM_8
 Palbociclib 72 1.3076 0.2218 0.2364 0.78812 0.1724 0.8353 0.9515
3.06659142524e-11
MCF10A-GM_2
 Palbociclib 72 0.5075 0.1059 0.3396 0.44124 0.0438 0.6549 0.9544
1.88525861589e-11
MCF10A-GM_1
 Alpelisib 72 8.2016 0.4069 0.1540 65.49912 -1.0000 0.5288 0.9578
7.77156117238e-16
MCF10A-GM_9
 Alpelisib 72 11.2837 0.4721 0.1219 77.89622 -1.0000 0.5686 0.9588
5.55111512313e-16
MCF10A-GM_5
 Dasatinib 72 0.3227 -0.1921 0.4426 0.48669 -0.1945 0.7999 0.9614
3.33066907388e-16
MCF10A-GM_2
 Alpelisib 72 7.3886 0.4254 0.1560 53.37110 -1.0000 0.5556 0.9629
2.22044604925e-16
MCF10A-GM_2
 Dasatinib 72 0.3007 -0.1486 0.4680 0.61942 -0.3062 0.6611 0.9635
1.11022302463e-16
MCF10A-GM_8
 Dasatinib 72 0.3362 -0.1510 0.4405 0.46460 -0.1541 0.8309 0.9643
1.11022302463e-16
MCF10A-GM_3
 Alpelisib 72 7.4487 0.4036 0.1516 49.04215 -1.0000 0.5829 0.9653
1.11022302463e-16
MCF10A-GM_7
 Palbociclib 72 1.2911 0.1975 0.2446 0.98102 0.0926 0.7453 0.9668
1.48003831413e-12
MCF10A-GM_5
 Alpelisib 72 8.5470 0.4318 0.1327 54.70483 -1.0000 0.5918 0.9673
1.11022302463e-16
MCF10A-GM_7
 Dasatinib 72 0.3822 -0.1253 0.4260 0.60000 -0.2136 0.7889 0.9676
1.11022302463e-16
MCF10A-GM_1
 Palbociclib 72 0.3755 0.0386 0.3583 0.32427 0.0472 0.6762 0.9684
9.82769421398e-13
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