LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Vorinostat | 80.82 | 13.4 | 3.3561 | 3.3984 | -0.0514 | -0.0324 | 5.0000 | 0.1236 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.82 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Trametinib | 80.82 | 13.4 | 0.0466 | 0.0449 | 0.0168 | 0.0770 | 4.4772 | 0.3291 |
| MCF 10A-H2B-mCherry | Etoposide | 80.82 | 13.4 | 0.4706 | 0.4799 | -0.2090 | -0.0541 | 4.9985 | 0.3977 |
| MCF 10A-H2B-mCherry | Taxol | 80.82 | 13.4 | 0.0029 | 0.0033 | -0.4208 | -0.4210 | 5.0000 | 0.7492 |
| MCF 10A-H2B-mCherry | Dasatinib | 80.82 | 13.4 | 2.6268 | 3.1186 | -0.6670 | -0.6812 | 5.0000 | 0.2539 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.60 | 13.4 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0077 |
| MCF 10A-H2B-mCherry | Dasatinib | 78.60 | 13.4 | 2.6077 | 3.0672 | -0.6115 | -0.6256 | 5.0000 | 0.2331 |
| MCF 10A-H2B-mCherry | Vorinostat | 78.60 | 13.4 | 3.6487 | 3.6037 | 0.0164 | 0.0174 | 5.0000 | 0.0967 |
| MCF 10A-H2B-mCherry | Etoposide | 78.60 | 13.4 | 0.4984 | 0.5033 | -0.1109 | -0.0202 | 3.8858 | 0.3607 |
| MCF 10A-H2B-mCherry | Taxol | 78.60 | 13.4 | 0.0027 | 0.003 | -0.4567 | -0.3897 | 5.0000 | 0.7535 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Trametinib | 78.60 | 13.4 | 0.0337 | 0.0328 | 0.0005 | 0.0659 | 5.0000 | 0.3496 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Neratinib | 76.38 | 13.4 | 1.1623 | 1.4074 | -0.3862 | -0.4851 | 3.9610 | 0.2050 |
| MCF 10A-H2B-mCherry | Taxol | 76.38 | 13.4 | 0.0027 | 0.003 | -0.3872 | -0.2827 | 5.0000 | 0.7081 |
| MCF 10A-H2B-mCherry | Vorinostat | 76.38 | 13.4 | 3.3759 | 3.4083 | -0.0226 | -0.0245 | 5.0000 | 0.1154 |
| MCF 10A-H2B-mCherry | Trametinib | 76.38 | 13.4 | 0.0309 | 0.0305 | -0.0623 | 0.0243 | 5.0000 | 0.3705 |
| MCF 10A-H2B-mCherry | Dasatinib | 76.38 | 13.4 | 2.6411 | 3.1142 | -0.6260 | -0.6410 | 5.0000 | 0.2153 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.38 | 13.4 | Inf | Inf | 0.9533 | 0.9533 | 0.0000 | -0.0076 |
| MCF 10A-H2B-mCherry | Etoposide | 76.38 | 13.4 | 0.4846 | 0.465 | -0.0425 | 0.0666 | 4.0059 | 0.3424 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.38 | 13.4 | 3.7937 | 3.9931 | 0.0653 | -0.0691 | 2.1758 | 0.1012 |
| MCF 10A-H2B-mCherry | Trametinib | 74.16 | 13.4 | 0.0303 | 0.0298 | -0.0034 | 0.0350 | 5.0000 | 0.3753 |