LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)

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Cell Small Molecule Time Point (hr) Time Interval (hr) GR50 GEC50 GRmax GRinf GR Hill Coefficient GR_AOC
MCF 10A-H2B-mCherry Neratinib 15.91 13.5
0.0344
0.0274
 0.1224 0.1444 1.4878 0.4548
MCF 10A-H2B-mCherry Dasatinib 15.91 13.5
0.3062
0.1466
 0.1432 0.2293 0.8331 0.3528
MCF 10A-H2B-mCherry Alpelisib 15.91 13.5
18.5716
168.3795
 0.5685 -1.0000 0.4983 0.1166
MCF 10A-H2B-mCherry Etoposide 15.91 13.5
0.4653
0.5125
 -0.0077 -0.0631 1.2303 0.3605
MCF 10A-H2B-mCherry Vorinostat 15.91 13.5
0.673
1.0022
 -0.2338 -0.3147 1.2258 0.4090
MCF 10A-H2B-mCherry Trametinib 15.91 13.5
0.0058
0.003
 0.3307 0.3502 1.7943 0.4481
MCF 10A-H2B-mCherry Palbociclib 15.91 13.5
0.045
0.0365
 0.1252 0.0905 0.9568 0.5703
MCF 10A-H2B-mCherry Taxol 15.91 13.5
0.0055
0.0121
 -0.6952 -0.7201 1.1326 0.6312
MCF 10A-H2B-mCherry Taxol 16.73 13.3
0.0047
0.0097
 -0.6834 -0.7046 1.2187 0.6742
MCF 10A-H2B-mCherry Vorinostat 16.73 13.3
0.6881
1.3581
 -0.2534 -0.4659 0.9685 0.4010
MCF 10A-H2B-mCherry Palbociclib 16.73 13.3
0.0533
0.0647
 0.0467 -0.0559 0.5491 0.5897
MCF 10A-H2B-mCherry Trametinib 16.73 13.3
0.0054
0.0032
 0.1822 0.2568 1.3893 0.5061
MCF 10A-H2B-mCherry Dasatinib 16.73 13.3
0.2398
0.1356
 0.1161 0.2329 1.0987 0.3477
MCF 10A-H2B-mCherry Neratinib 16.73 13.3
0.0359
0.03
 0.1415 0.1416 1.8404 0.4507
MCF 10A-H2B-mCherry Etoposide 16.73 13.3
0.56
0.6179
 -0.0203 -0.0675 1.2871 0.3359
MCF 10A-H2B-mCherry Alpelisib 16.73 13.3
19.6489
124.3425
 0.6341 -0.9991 0.5951 0.0849
MCF 10A-H2B-mCherry Vorinostat 18.59 13.3
0.5664
1.0687
 -0.2412 -0.4101 0.9460 0.4283
MCF 10A-H2B-mCherry Taxol 18.59 13.3
0.0034
0.0077
 -0.7352 -0.7179 1.1107 0.7117
MCF 10A-H2B-mCherry Etoposide 18.59 13.3
0.4472
0.5118
 -0.0195 -0.0809 1.1143 0.3622
MCF 10A-H2B-mCherry Alpelisib 18.59 13.3
16.2872
30.1363
 0.5697 -0.4075 0.6604 0.1016
MCF 10A-H2B-mCherry Palbociclib 18.59 13.3
0.0539
0.0586
 0.0305 -0.0240 0.8136 0.5912
MCF 10A-H2B-mCherry Dasatinib 18.59 13.3
0.1649
0.1073
 0.0926 0.2004 1.1913 0.3926
MCF 10A-H2B-mCherry Neratinib 18.59 13.3
0.0297
0.0273
 0.0756 0.0682 1.7219 0.4978
MCF 10A-H2B-mCherry Trametinib 18.59 13.3
0.0031
0.0024
 0.1609 0.1780 1.5913 0.5859
MCF 10A-H2B-mCherry Taxol 20.81 13.3
0.0024
0.0055
 -0.7843 -0.7290 1.0789 0.7803
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