LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 23.04 | 13.3 | 13.0191 | 67.1327 | 0.5327 | -1.0000 | 0.6881 | 0.0949 |
| MCF 10A-H2B-mCherry | Alpelisib | 15.91 | 13.5 | 18.5716 | 168.3795 | 0.5685 | -1.0000 | 0.4983 | 0.1166 |
| MCF 10A-H2B-mCherry | Alpelisib | 20.81 | 13.3 | 15.1045 | 119.1663 | 0.5557 | -1.0000 | 0.5491 | 0.1104 |
| MCF 10A-H2B-mCherry | Alpelisib | 40.81 | 13.3 | 42.2866 | 311.4568 | 0.7077 | -1.0000 | 0.5651 | 0.0697 |
| MCF 10A-H2B-mCherry | Alpelisib | 27.48 | 13.3 | 20.0615 | 109.7735 | 0.5940 | -1.0000 | 0.7179 | 0.0765 |
| MCF 10A-H2B-mCherry | Neratinib | 78.60 | 13.4 | 1.6879 | 2.4766 | -0.2708 | -1.0000 | 3.5041 | 0.1709 |
| MCF 10A-H2B-mCherry | Neratinib | 80.82 | 13.4 | 2.3453 | 2.9216 | -0.1941 | -0.9999 | 5.0000 | 0.1566 |
| MCF 10A-H2B-mCherry | Alpelisib | 16.73 | 13.3 | 19.6489 | 124.3425 | 0.6341 | -0.9991 | 0.5951 | 0.0849 |
| MCF 10A-H2B-mCherry | Alpelisib | 36.36 | 13.3 | 42.9745 | 417.2033 | 0.6921 | -0.9983 | 0.4876 | 0.0807 |
| MCF 10A-H2B-mCherry | Alpelisib | 43.03 | 13.3 | 23.3924 | 88.1783 | 0.7153 | -0.9969 | 0.8352 | 0.0518 |
| MCF 10A-H2B-mCherry | Dasatinib | 49.69 | 13.3 | 1.5612 | 5.8184 | -0.1606 | -0.9355 | 0.8455 | 0.2645 |
| MCF 10A-H2B-mCherry | Alpelisib | 25.25 | 13.3 | 13.7447 | 50.8693 | 0.5662 | -0.9329 | 0.8377 | 0.0699 |
| MCF 10A-H2B-mCherry | Dasatinib | 47.47 | 13.3 | 1.2344 | 5.6634 | -0.1100 | -0.9056 | 0.6840 | 0.2827 |
| MCF 10A-H2B-mCherry | Alpelisib | 38.59 | 13.3 | Inf | 659.7431 | 0.7083 | -0.8898 | 0.4399 | 0.0784 |
| MCF 10A-H2B-mCherry | Alpelisib | 29.70 | 13.3 | 27.7483 | 154.7888 | 0.6373 | -0.8744 | 0.6097 | 0.0762 |
| MCF 10A-H2B-mCherry | Dasatinib | 45.25 | 13.3 | 1.0589 | 4.5149 | -0.0802 | -0.7836 | 0.6356 | 0.2946 |
| MCF 10A-H2B-mCherry | Palbociclib | 65.24 | 13.3 | 1.9881 | 6.2593 | -0.0570 | -0.7577 | 0.8015 | 0.1967 |
| MCF 10A-H2B-mCherry | Dasatinib | 40.81 | 13.3 | 0.6387 | 3.8735 | -0.0618 | -0.7504 | 0.4977 | 0.3511 |
| MCF 10A-H2B-mCherry | Dasatinib | 43.03 | 13.3 | 0.7522 | 3.8263 | -0.0651 | -0.7385 | 0.5434 | 0.3324 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Taxol | 20.81 | 13.3 | 0.0024 | 0.0055 | -0.7843 | -0.7290 | 1.0789 | 0.7803 |
| MCF 10A-H2B-mCherry | Neratinib | 74.16 | 13.4 | 1.0683 | 1.3539 | -0.4211 | -0.7255 | 3.7652 | 0.1930 |
| MCF 10A-H2B-mCherry | Taxol | 15.91 | 13.5 | 0.0055 | 0.0121 | -0.6952 | -0.7201 | 1.1326 | 0.6312 |
| MCF 10A-H2B-mCherry | Taxol | 18.59 | 13.3 | 0.0034 | 0.0077 | -0.7352 | -0.7179 | 1.1107 | 0.7117 |
| MCF 10A-H2B-mCherry | Dasatinib | 38.59 | 13.3 | 0.5386 | 3.3837 | -0.0418 | -0.7129 | 0.4750 | 0.3711 |