LINCS MCF 10A Common Project: Rolling-time-point sensitivity measures of the MCF 10A breast cell line to 8 small molecule perturbagens. Dataset 13 of 15: Time-dependent dose-response metrics for biological replicate 1. - Dataset (ID:20321)
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| Cell | Small Molecule | Time Point (hr) | Time Interval (hr) | GR50 | GEC50 | GRmax | GRinf | GR Hill Coefficient | GR_AOC |
|---|---|---|---|---|---|---|---|---|---|
| MCF 10A-H2B-mCherry | Alpelisib | 60.80 | 13.3 | Inf | Inf | 0.7722 | 0.8272 | 1.1247 | 0.0073 |
| MCF 10A-H2B-mCherry | Alpelisib | 58.58 | 13.3 | Inf | 14.2616 | 0.7902 | -0.1257 | 1.4055 | 0.0230 |
| MCF 10A-H2B-mCherry | Alpelisib | 78.60 | 13.4 | Inf | Inf | 1.0500 | 1.0500 | 0.0000 | -0.0077 |
| MCF 10A-H2B-mCherry | Alpelisib | 38.59 | 13.3 | Inf | 659.7431 | 0.7083 | -0.8898 | 0.4399 | 0.0784 |
| MCF 10A-H2B-mCherry | Alpelisib | 63.02 | 13.3 | Inf | Inf | 0.8310 | 0.8049 | 0.7013 | 0.0213 |
| MCF 10A-H2B-mCherry | Alpelisib | 80.82 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 74.16 | 13.4 | Inf | Inf | 1.0285 | 1.0285 | 0.0000 | -0.0023 |
| MCF 10A-H2B-mCherry | Alpelisib | 31.92 | 13.3 | Inf | 48.0469 | 0.6505 | -0.3257 | 0.5441 | 0.0840 |
| MCF 10A-H2B-mCherry | Alpelisib | 71.94 | 13.4 | Inf | Inf | 0.9804 | 0.9804 | 0.0000 | -0.0105 |
| MCF 10A-H2B-mCherry | Alpelisib | 67.47 | 13.3 | Inf | Inf | 0.8446 | 0.8821 | 2.5000 | 0.0200 |
| MCF 10A-H2B-mCherry | Alpelisib | 65.24 | 13.3 | Inf | Inf | 0.7691 | 0.8264 | 2.5000 | 0.0249 |
| MCF 10A-H2B-mCherry | Alpelisib | 69.71 | 13.4 | Inf | Inf | 0.8659 | 0.8659 | 0.0000 | 0.0193 |
| MCF 10A-H2B-mCherry | Alpelisib | 76.38 | 13.4 | Inf | Inf | 0.9533 | 0.9533 | 0.0000 | -0.0076 |
| MCF 10A-H2B-mCherry | Alpelisib | 45.25 | 13.3 | Inf | 19.4732 | 0.7923 | -0.0908 | 3.0690 | 0.0228 |
| MCF 10A-H2B-mCherry | Alpelisib | 47.47 | 13.3 | Inf | 17.0493 | 0.7926 | -0.0881 | 3.2633 | 0.0135 |
| MCF 10A-H2B-mCherry | Alpelisib | 49.69 | 13.3 | Inf | 15.168 | 0.7888 | -0.0845 | 3.1051 | 0.0197 |
| MCF 10A-H2B-mCherry | Alpelisib | 51.92 | 13.3 | Inf | 21.8307 | 0.7677 | -0.1382 | 1.2490 | 0.0308 |
| MCF 10A-H2B-mCherry | Alpelisib | 54.14 | 13.3 | Inf | 12.3614 | 0.7650 | -0.1089 | 1.4676 | 0.0227 |
| MCF 10A-H2B-mCherry | Alpelisib | 56.36 | 13.3 | Inf | 12.6838 | 0.7979 | -0.0976 | 1.4912 | 0.0136 |
| MCF 10A-H2B-mCherry | Palbociclib | 80.82 | 13.4 | 4.3569 | 6.7523 | -0.0503 | -0.7295 | 1.9672 | 0.0940 |
| MCF 10A-H2B-mCherry | Alpelisib | 36.36 | 13.3 | 42.9745 | 417.2033 | 0.6921 | -0.9983 | 0.4876 | 0.0807 |
| MCF 10A-H2B-mCherry | Alpelisib | 40.81 | 13.3 | 42.2866 | 311.4568 | 0.7077 | -1.0000 | 0.5651 | 0.0697 |
| MCF 10A-H2B-mCherry | Palbociclib | 78.60 | 13.4 | 3.8114 | 5.377 | -0.0290 | -0.5698 | 2.1381 | 0.1010 |
| MCF 10A-H2B-mCherry | Palbociclib | 76.38 | 13.4 | 3.7937 | 3.9931 | 0.0653 | -0.0691 | 2.1758 | 0.1012 |
| MCF 10A-H2B-mCherry | Vorinostat | 78.60 | 13.4 | 3.6487 | 3.6037 | 0.0164 | 0.0174 | 5.0000 | 0.0967 |